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Endocrinology is a branch of medicine dealing with disorder of the endocrine system and its specific secretions called hormones, the integration of developmental events such as proliferation, growth, and differentiation (including histogenesis and organogenesis) and the coordination of metabolism, respiration, excretion, movement, reproduction, and sensory perception depend on chemical cues, substances synthesised and secreted by specialized cells.
Obesity raises Lynch syndrome CRC risk

Obesity raises Lynch syndrome CRC risk

Obesity increases the risk of colorectal cancer in patients with Lynch syndrome, research indicates, but daily aspirin use may combat this excess risk. [More]
New study reveals effect of light exposure at night on the biology of teen sleep

New study reveals effect of light exposure at night on the biology of teen sleep

A new study has an important implication for tweens and young teens as they head back to school: Taking a gadget to bed could really hurt their sleep. [More]
New assessment tool under development can help detect physical traits of Klinefelter syndrome

New assessment tool under development can help detect physical traits of Klinefelter syndrome

Klinefelter syndrome is the most common disorder of the male sex chromosomes, yet is rarely diagnosed in children. A new assessment tool is being developed by researchers at Columbia University Medical Center (CUMC) to help pediatricians detect the physical traits of the syndrome. The tool could pave the way for early interventions that prevent and treat a range of physical, psychological, social, and cognitive impairments. [More]
New genome-wide association study sheds light on the underlying biology of polycystic ovary syndrome

New genome-wide association study sheds light on the underlying biology of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) has been passed down in many families for generations -- causing reproductive and metabolic health problems for millions of women around the world. Yet, its cause remains unknown despite more than 80 years of research since the disorder was first described in 1935. [More]
Common diabetes drug metformin works in gut, not the bloodstream

Common diabetes drug metformin works in gut, not the bloodstream

Although metformin was introduced as a treatment for type 2 diabetes nearly 60 years ago and is now the recommended first-line treatment for newly diagnosed patients, researchers still debate precisely how the drug works. [More]
Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Intarcia Therapeutics, Inc. today announced positive top-line results from its 52-week Phase 3 FREEDOM-2 clinical trial to determine the comparative efficacy of the company's late-stage investigational candidate ITCA 650 to Merck's Januvia in reducing HbA1c in patients with type 2 diabetes following a year of treatment. [More]
FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Chiasma, Inc., a U.S. late-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application (NDA) for the marketing and sale of octreotide capsules, an oral drug proposed for the maintenance therapy of adult patients with acromegaly. [More]
Iodine supplementation during pregnancy can save costs for health care systems, society

Iodine supplementation during pregnancy can save costs for health care systems, society

Giving all pregnant women iodine supplements, even in mildly iodine deficient countries like the UK, could result in huge cost savings for health care systems and society, according to new modelling research published in The Lancet Diabetes & Endocrinology journal. [More]
Retrieving eggs at earlier stage of fertility treatment may improve pregnancy rates for older women

Retrieving eggs at earlier stage of fertility treatment may improve pregnancy rates for older women

IVF success rates for women aged 43 and above could improve by retrieving eggs from their ovaries at an earlier stage of fertility treatment, according to a new study published today in the Journal of Endocrinology. [More]
Aeterna Zentaris reports that DSMB scheduled to close second interim analysis of ZoptEC Phase 3 trial in early October

Aeterna Zentaris reports that DSMB scheduled to close second interim analysis of ZoptEC Phase 3 trial in early October

Aeterna Zentaris Inc. today announced that the independent Data and Safety Monitoring Board for the pivotal Phase 3 ZoptEC (Zoptarelin Doxorubicin in Endometrial Cancer) study with zoptarelin doxorubicin in women with advanced, recurrent or metastatic endometrial cancer, will complete a pre-specified second interim efficacy and safety analysis of the compound in early October 2015. [More]
Scientists publish new important clues about marrow fat

Scientists publish new important clues about marrow fat

While most of us worry about the fat cells building up on the fleshy parts of our bodies, scientists have started to pay serious attention to another kind of fat cell deep inside our bones, in what's called the marrow. [More]
BIDMC scientists discover new vitamin B3 pathway that regulates liver metabolism

BIDMC scientists discover new vitamin B3 pathway that regulates liver metabolism

Researchers at Beth Israel Deaconess Medical Center have identified a new vitamin B3 pathway that regulates liver metabolism. The discovery provides an opportunity to pursue the development of novel drug therapies to address obesity, type 2 diabetes and related metabolic diseases. [More]
IUPUI researchers receive NIH grant to study effect of depression treatment on cardiovascular disease

IUPUI researchers receive NIH grant to study effect of depression treatment on cardiovascular disease

Indiana University-Purdue University Indianapolis researchers led by Jesse Stewart of the School of Science, have received a $2.6 million grant from the National Institutes of Health to conduct the first randomized controlled trial to determine whether depression treatment can help prevent the development of cardiovascular disease. [More]
Bioenergetic analysis of pancreatic beta-cells shows impaired metabolic signature in type 2 diabetes patients

Bioenergetic analysis of pancreatic beta-cells shows impaired metabolic signature in type 2 diabetes patients

Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes. The cause of this dysfunction has been unknown. Publishing online in Endocrinology, Buck Institute assistant research professor Akos Gerencser, PhD, shows that in patients with type 2 diabetes the balance between supply and demand of the mitochondrial membrane potential (ΔψM) is altered causing a decrease in the signaling that turns on insulin secretion. [More]
Low blood level of 4 proteins can help diabetics protect against immune attack

Low blood level of 4 proteins can help diabetics protect against immune attack

Patients with type 1 diabetes have significantly lower blood levels of four proteins that help protect their tissue from attack by their immune system, scientists report. [More]
Endocrine Society recommends removal of tumor as first-line treatment for endogenous Cushing's syndrome

Endocrine Society recommends removal of tumor as first-line treatment for endogenous Cushing's syndrome

The Endocrine Society today issued a Clinical Practice Guideline (CPG) on strategies for treating Cushing's syndrome, a condition caused by overexposure to the hormone cortisol. [More]
Aeterna Zentaris selects optimized Erk inhibitor molecule for further development

Aeterna Zentaris selects optimized Erk inhibitor molecule for further development

Aeterna Zentaris Inc. today announced it has selected an optimized Erk inhibitor molecule for development, thus achieving another important milestone in the development of a new class of potential cancer therapies. [More]
German life sciences entrepreneurs granted option to develop Aeterna Zentaris’ oral allogenic tumor vaccine technology

German life sciences entrepreneurs granted option to develop Aeterna Zentaris’ oral allogenic tumor vaccine technology

Aeterna Zentaris Inc. today announced that it has granted to German life sciences entrepreneurs with a proven track-record of funding the development and commercialization of biotechnology, an option to license the Company's live recombinant oral allogenic tumor vaccine technology, including AEZS-120, the most advanced product candidate for prostate cancer which is ready to enter a Phase 1 clinical trial. [More]
Biologists identify genetic mechanisms behind anti-inflammatory impact of cortisone

Biologists identify genetic mechanisms behind anti-inflammatory impact of cortisone

There's no time to lose when an emergency doctor diagnoses „Shock lung!" at the accident scene. What physicians know as "acute lung injury" (ALI) otherwise leads to death by suffocation without immediate treatment. [More]
New book provides overview of treatment options for paediatric calcium and bone disorders

New book provides overview of treatment options for paediatric calcium and bone disorders

Knowledge about paediatric calcium and bone disorders has increased rapidly over the past twenty years. Great advances have been made in the underlying genetic basis for many conditions, in bone density and geometry imaging and in the development of new treatment options, calling for a new edition of 'Calcium and Bone Disorders in Children and Adolescents' which was first published in 2009. [More]
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