Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Experts develop clinical practice guidance for exercise assessments in people with cystic fibrosis

People living with cystic fibrosis (CF) will benefit from improved treatment as international experts produce clinical practice guidance for exercise assessments.

10 Aug 2023

Yale researchers create "humanized" liver in living mice to study chronic liver diseases

Yale researchers have created a functional "humanized" liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of people in the United States.

9 Aug 2023

CT imaging reveals that COVID-19 vaccination may protect against severe lung pathology

Researchers determine how COVID-19 vaccination influences lung-sequelae-related pathology and the manifestation of severe infection.

9 Aug 2023

Sugar-sweetened beverages linked to increased risk of liver cancer and chronic liver disease mortality

Approximately 65% of adults in the United States consume sugar sweetened beverages daily. Chronic liver disease is a major cause of morbidity and mortality worldwide and can result in liver cancer and liver disease-related mortality.

8 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Impact of age-related alterations in lipid metabolism on general health

Scientists provide a detailed overview on age-related alterations in lipid metabolism and its association with age-related chronic diseases.

8 Aug 2023

Insilico Medicine's new AI tool shows promise in predicting clinical trial outcomes

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has demonstrated that it can predict the outcome of Phase II to Phase III clinical trial success using its proprietary transformer-based AI clinical trial prediction tool called inClinico with a high degree of accuracy.

3 Aug 2023

UC San Diego team reports new insights on pelvic floor muscle dysfunction

University of California San Diego researchers are leading a team reporting new insights in Science Translational Medicine on pelvic floor muscle (PFM) dysfunction, which is one of the key risk factors for pelvic floor disorders which impact close to a quarter of women in the U.S.

2 Aug 2023

Insilico Medicine uses AI to discover novel SIK2 inhibitors

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.

2 Aug 2023

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

Scientists determine whether physical activity can be used as an effective intervention to mitigate obesity-related inflammation in diabetes.

1 Aug 2023

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Researchers summarize available data on pyroptosis in the context of renal fibrosis, as well as its prevention and treatment.

1 Aug 2023

Two new subtypes of HPV+ head and neck cancers identified

Cases of human papillomavirus (HPV)-associated cancers of the head and neck, known as head and neck squamous cell carcinoma (HNSCC), are rapidly increasing throughout the United States.

31 Jul 2023

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Human senescent fibroblasts trigger progressive lung fibrosis in mice."

31 Jul 2023

Late diagnosis of cystic fibrosis leads to poorer long-term health outcomes, study finds

The Journal of Pediatrics has published a manuscript by Stacey Martiniano, MD, pulmonary specialist at Children's Hospital Colorado and associate professor of pediatrics at the University of Colorado.

31 Jul 2023

Study suggests global longitudinal strain is a powerful independent predictor of adverse outcomes in patients with heart failure and diabetes

Researchers determine the prognostic significance of GLS by cardiac magnetic resonance and identify plasma biomarkers linked with fibrosis and inflammation.

31 Jul 2023

New study findings underscore the importance of timely newborn screenings in early care for cystic fibrosis

29 Jul 2023

RNF41 protein could be a new therapeutic target against cirrhosis and liver inflammation

The RNF41 protein could be a new therapeutic target in the fight against two chronic liver diseases: cirrhosis and liver inflammation.

28 Jul 2023

Researchers seek to understand the Achilles' heel of insulin pump technology

Since the insulin pump started widespread use in the early 1980s, it's become the option of choice for type 1 diabetes patients to manage their glucose levels in a way that doesn't require testing their blood sugar and injecting insulin multiple times daily.

27 Jul 2023

Children's Colorado announces launch of the Precision Medicine Institute

Children's Hospital Colorado (Children's Colorado) today announced the launch of the Precision Medicine Institute, which will allow experts to more efficiently integrate precision medicine into care provided to patients throughout the hospital.

26 Jul 2023

Meclofenamate shows promise in treating abnormal respiratory mucus

Our respiratory system is lined with a thin fluid layer called mucus on the inside. The mucus protects us from inhaling harmful and unwanted airborne agents from germs to pollutants; it achieves this feat due to its unique gel-like texture imparted by proteins called mucins.

25 Jul 2023

Fibrosis News and Research

Further Reading

Experts develop clinical practice guidance for exercise assessments in people with cystic fibrosis

Yale researchers create "humanized" liver in living mice to study chronic liver diseases

CT imaging reveals that COVID-19 vaccination may protect against severe lung pathology

Sugar-sweetened beverages linked to increased risk of liver cancer and chronic liver disease mortality

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Impact of age-related alterations in lipid metabolism on general health

Insilico Medicine's new AI tool shows promise in predicting clinical trial outcomes

UC San Diego team reports new insights on pelvic floor muscle dysfunction

Insilico Medicine uses AI to discover novel SIK2 inhibitors

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Two new subtypes of HPV+ head and neck cancers identified

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

Late diagnosis of cystic fibrosis leads to poorer long-term health outcomes, study finds

Study suggests global longitudinal strain is a powerful independent predictor of adverse outcomes in patients with heart failure and diabetes

New study findings underscore the importance of timely newborn screenings in early care for cystic fibrosis

RNF41 protein could be a new therapeutic target against cirrhosis and liver inflammation

Researchers seek to understand the Achilles' heel of insulin pump technology

Children's Colorado announces launch of the Precision Medicine Institute

Meclofenamate shows promise in treating abnormal respiratory mucus

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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