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Eculizumab drug provides new hope for kidney failure patients

Eculizumab drug provides new hope for kidney failure patients

Surgeons at the University of Illinois Hospital & Health Sciences System have — for the first time — used an orphan drug to prevent rejection of a kidney transplanted from a living donor with a mismatched blood type. [More]
Misuse of anabolic steroids may increase heart problems in ARVC patients

Misuse of anabolic steroids may increase heart problems in ARVC patients

Research has already shown that taking anabolic steroids is associated with high blood pressure and an increased risk of developing heart conditions such as left ventricular hypertrophy. [More]
Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Preeclampsia is one of the most common complications to occur during pregnancy, yet its causes are still unknown. A new study involving patients, cell cultures and animal experiments has now shown that those affected by the disease have lower quantities of the placenta's immune protein CD74, and that certain inflammatory factors are higher. These factors disrupt the formation of the placenta and leave the fetus undernourished. [More]
DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

Dopamine signaling in the kidneys plays a critical role in blood pressure regulation and is responsible for nearly half of the salt and water excretion that occurs in response to increased dietary salt intake. Notably, genetic deletion of any of the 5 dopamine receptors expressed in the kidney causes hypertension in mice. [More]
REGARDS study shows persistence of racial disparities in stroke incidence, mortality

REGARDS study shows persistence of racial disparities in stroke incidence, mortality

Blacks between the ages of 45 and 54 die of strokes at a rate that is three times greater than their white counterparts, according to the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, which looked at stroke incidence and mortality of nearly 30,000 participants over the age of 45 from an ethnically and demographically diverse sample of the U.S. population. [More]
Black men with high degree of West African genetic ancestry have less central adiposity

Black men with high degree of West African genetic ancestry have less central adiposity

Among black men, those with more genetic variants descended from West Africa may have a relatively lower risk of being overweight, obese and diabetic, according to a new study out of the University of Alabama at Birmingham and University of Arizona. [More]
Excess phosphates in foods may lead to abnormally high blood pressure

Excess phosphates in foods may lead to abnormally high blood pressure

Excess consumption of phosphate over-activates nerves that raise blood pressure, leading to abnormally high blood pressure, a new study in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology reports. [More]
New urine-based diagnostic method may help detect preeclampsia in pregnant women

New urine-based diagnostic method may help detect preeclampsia in pregnant women

A team of scientists from the Federal State Budget Institution "Research Center for Obstetrics, Gynecology and Perinatology", Moscow Institute of Physics and Technology, the Emanuel Institute for Biochemical Physics, and the Talrose Institute for Energy Problems of Chemical Physics have developed an approach for a method of non-invasive testing for pregnant women with a serious and complex condition called preeclampsia. [More]
Children with strong family history of type 2 diabetes or CVD prone to have high cholesterol levels

Children with strong family history of type 2 diabetes or CVD prone to have high cholesterol levels

A new study published in Diabetologia (the journal of the European Association for the Study of Diabetes shows that children with a strong family history of cardiovascular disease (CVD) and/or type 2 diabetes were found to have cholesterol levels significantly higher than children with no family history of those conditions. [More]
Overcoming barriers to move beyond race-based treatment decisions

Overcoming barriers to move beyond race-based treatment decisions

Prescribing certain medications on the basis of a patient's race has long come under fire from those uneasy with using race as a surrogate for biology when treating disease. [More]
Self-care can help nurses manage compassion fatigue

Self-care can help nurses manage compassion fatigue

The heart of healthcare is stressed. With longer shifts, staffing shortages and healthcare changes taxing our nurses, it's no surprise that up to 80 percent report suffering compassion fatigue at some point in their careers, according to recent studies. [More]
Study finds gap in screening for lipid abnormalities among adults taking antipsychotic medications

Study finds gap in screening for lipid abnormalities among adults taking antipsychotic medications

Too few adults taking antipsychotic medications are being screened for abnormalities in lipids, which include cholesterol and triglycerides, new research from the University of Colorado Anschutz Medical Campus finds. [More]
Raging with anger may increase risk of cardiovascular problems

Raging with anger may increase risk of cardiovascular problems

Those who rage with frustration during a marital spat have an increased risk of cardiovascular problems such as chest pain or high blood pressure later in life, according to new research from Northwestern University and the University of California, Berkeley. [More]
Epigenetic modification of Igfbp2 gene may increase risk of obesity and fatty liver

Epigenetic modification of Igfbp2 gene may increase risk of obesity and fatty liver

Scientists of the German Center for Diabetes Research led by the German Institute of Human Nutrition have shown in a mouse model that the epigenetic modification of the Igfbp2 gene observed in the young animal precedes a fatty liver in the adult animal later in life. [More]
Tips for improving cardiovascular health

Tips for improving cardiovascular health

New research by UT Southwestern heart specialists shows that sedentary behavior such as sitting for long periods of time at a desk or on the couch is associated with increased amounts of calcium in the arteries, which in turn can lead to higher risk of heart attack. [More]
Aggressive blood pressure intervention can benefit frail adults aged 75 and older

Aggressive blood pressure intervention can benefit frail adults aged 75 and older

NIH-supported researchers are reporting additional details about a widely-publicized study that linked a systolic blood pressure target under 120 mm Hg (millimeters of mercury) with reduced cardiovascular disease and a lower risk of death. [More]
Low-salt diets may increase CVD risk and death compared to average salt consumption

Low-salt diets may increase CVD risk and death compared to average salt consumption

A large worldwide study has found that, contrary to popular thought, low-salt diets may not be beneficial and may actually increase the risk of cardiovascular disease (CVD) and death compared to average salt consumption. [More]
Intensive blood pressure lowering therapies can cut heart disease risk in older adults

Intensive blood pressure lowering therapies can cut heart disease risk in older adults

Intensive therapies to reduce high blood pressure can cut the risk of heart disease in older adults without increasing the risk for falls, according to doctors at Wake Forest Baptist Medical Center. [More]
Older, frail hypertensive adults could benefit from intensive lowering of blood pressure

Older, frail hypertensive adults could benefit from intensive lowering of blood pressure

Adults with hypertension who are age 75 years and older, including those who are frail and with poor overall health, could benefit from lowering their blood pressure below current medical guidelines. [More]
Study finds that ACS NSQIP Surgical Risk Calculator has excellent calibration

Study finds that ACS NSQIP Surgical Risk Calculator has excellent calibration

The American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator accurately estimates the chance of a patient experiencing postoperative complications, and its performance can improve with recalibration of the tool according to research findings appearing online in the Journal of the American College of Surgeons in advance of print publication. [More]
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