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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.
Brief sleep can significantly improve memory performance

Brief sleep can significantly improve memory performance

Generations of school students have gone to bed the night before a maths exam or a vocabulary test with their algebra book or vocabulary notes tucked under their pillow in the hope that the knowledge would somehow be magically transferred into their brains while they slept. [More]
Hypermethylation serves as protective barrier inhibiting development of ALS, FTD

Hypermethylation serves as protective barrier inhibiting development of ALS, FTD

Penn Medicine researchers have discovered that hypermethylation - the epigenetic ability to turn down or turn off a bad gene implicated in 10 to 30 percent of patients with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD) - serves as a protective barrier inhibiting the development of these diseases. [More]
Cannabis abuse affects long-term memory, finds new Northwestern Medicine study

Cannabis abuse affects long-term memory, finds new Northwestern Medicine study

Teens who were heavy marijuana users - smoking it daily for about three years -- had an abnormally shaped hippocampus and performed poorly on long-term memory tasks, reports a new Northwestern Medicine study. [More]
Existing epilepsy drug reverses aMCI in elderly patients at risk for Alzheimer's disease

Existing epilepsy drug reverses aMCI in elderly patients at risk for Alzheimer's disease

A novel therapeutic approach for an existing drug reverses a condition in elderly patients who are at high risk for dementia due to Alzheimer's disease, researchers at Johns Hopkins University found. [More]
Rat study reveals role of lead in schizophrenia

Rat study reveals role of lead in schizophrenia

A study of the brains of rats exposed to lead has uncovered striking similarities with what is known about the brains of human schizophrenia patients, adding compelling evidence that lead is a factor in the onset of schizophrenia. [More]
McGill researchers discover key epigenetic factor that controls development of hippocampus

McGill researchers discover key epigenetic factor that controls development of hippocampus

McGill researchers have discovered, for the first time, the importance of a key epigenetic regulator in the development of the hippocampus, a part of the brain associated with learning, memory and neural stem cells. [More]
Common antidepressant medications not helpful for people with mood, anxiety disorders

Common antidepressant medications not helpful for people with mood, anxiety disorders

Studies indicate that the majority of people with mood and anxiety disorders who receive the most commonly prescribed class of antidepressant medications, Selective Serotonin Reuptake Inhibitors or SSRI's, are not helped by these medications. SSRIs are designed to increase serotonin, a neurotransmitter in the brain that is key to maintenance of mood. [More]
Anxiety and déjà vu: an interview with Dr Christine Wells, Sheffield Hallam University

Anxiety and déjà vu: an interview with Dr Christine Wells, Sheffield Hallam University

It’s thought that the neural basis of déjà vu is located in the temporal lobes, a region of the brain strongly associated with the storage and retrieval of memories. One source of support for this is evidence from individuals with temporal lobe epilepsy, some of whom experience déjà vu episodes as part of seizure-related auras... [More]
New study challenges scientific theory about role of hippocampus in unconscious memory

New study challenges scientific theory about role of hippocampus in unconscious memory

A new study by a UT Dallas researcher challenges a long-accepted scientific theory about the role the hippocampus plays in our unconscious memory. [More]
Scientists show pattern of connectivity in newly-generated hippocampal neurons

Scientists show pattern of connectivity in newly-generated hippocampal neurons

Research by a team of scientists from Cologne, Munich and Mainz has shown an unprecedented degree of connectivity reorganization in newly-generated hippocampal neurons in response to experience, suggesting their direct contribution to the processing of complex information in the adult brain. [More]
New study heightens concerns over the detrimental impact of APOE ε4 in urban children

New study heightens concerns over the detrimental impact of APOE ε4 in urban children

A new study by researchers at the Universities of Montana, Carleton, and North Carolina, and the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele -- the most prevalent genetic risk for Alzheimer's disease -- upon cognition, olfaction, and metabolic brain indices in healthy urban children and teens. [More]
Resveratrol found in red grapes, peanuts may help prevent age-related decline in memory

Resveratrol found in red grapes, peanuts may help prevent age-related decline in memory

A compound found in common foods such as red grapes and peanuts may help prevent age-related decline in memory, according to new research published by a faculty member in the Texas A&M Health Science Center College of Medicine. [More]
Researchers identify a common pattern across different psychiatric disorders

Researchers identify a common pattern across different psychiatric disorders

In a study analyzing whole-brain images from nearly 16,000 people, researchers at the Stanford University School of Medicine identified a common pattern across a spectrum of psychiatric disorders that are widely perceived to be quite distinct. [More]
Researchers discover novel compound that helps curtail progression of temporal lobe epilepsy

Researchers discover novel compound that helps curtail progression of temporal lobe epilepsy

Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have found that a novel compound they discovered helps curtail the onset and progression of temporal lobe epilepsy. [More]
ADDF awards grant to support initiation of AGB101 Phase 3 trial for aMCI treatment

ADDF awards grant to support initiation of AGB101 Phase 3 trial for aMCI treatment

The Alzheimer's Drug Discovery Foundation announced today a $900,000 grant to AgeneBio, a pharmaceutical company developing innovative therapies for neurologic and psychiatric diseases. The grant will support the initiation of an FDA-registered Phase 3 clinical trial of AGB101, a new therapeutic treatment for amnestic mild cognitive impairment (aMCI). [More]
International scientists take new path in epilepsy research

International scientists take new path in epilepsy research

An international team of scientists together with the University of Bonn Hospital have taken a new path in the research into causes of epilepsy: The researchers determined the networks of the active genes and, like a dragnet, looked for the "main perpetrators" using a computer model. [More]
Study uses 'systems genetics' approach to identify potential target for epilepsy

Study uses 'systems genetics' approach to identify potential target for epilepsy

A single gene that coordinates a network of about 400 genes involved in epilepsy could be a target for new treatments, according to research. [More]
UCLA researchers find new treatment that restores normal social behavior in autism mice model

UCLA researchers find new treatment that restores normal social behavior in autism mice model

Among the problems people with Autism spectrum disorders (ASD) struggle with are difficulties with social behavior and communication. That can translate to an inability to make friends, engage in routine conversations, or pick up on the social cues that are second nature to most people. Similarly, in a mouse model of ASD, the animals, like humans, show little interest in interacting or socializing with other mice. [More]
USC neuroscientists find potential prevention for Alzheimer's disease

USC neuroscientists find potential prevention for Alzheimer's disease

University of Southern California neuroscientists may have unlocked another puzzle to preventing risks that can lead to Alzheimer's disease. Researchers at Keck Medicine of USC used high-resolution imaging of the living human brain to show for the first time that the brain's protective blood barrier becomes leaky with age, starting at the hippocampus, a critical learning and memory center that is damaged by Alzheimer's disease. [More]
Learning technique may help overcome cognitive issues in fragile X syndrome

Learning technique may help overcome cognitive issues in fragile X syndrome

A learning technique that maximizes the brain's ability to make and store memories may help overcome cognitive issues seen in fragile X syndrome, a leading form of intellectual disability, according to UC Irvine neurobiologists. [More]
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