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Researchers discover hotspot L205R mutation is closely associated with adrenocortical tumors

Researchers discover hotspot L205R mutation is closely associated with adrenocortical tumors

Chinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI, and other institutions have discovered that the activating hotspot L205R mutation in PRKACA gene was closely associated with adrenocortical tumors (ACTs), and the relationship of recurrently mutated DOT1L and CLASP2 with ACTs' other subtypes. [More]

Antimuscarinics plus α-blockers ‘recommended for male LUTS’

Antimuscarinics “could and should” be used in the pharmacological treatment of men with lower urinary tract symptoms caused by benign prostatic hyperplasia or bladder outlet obstruction, say the authors of a meta-analysis published in Urology. [More]
Endo Health Solutions Reports net loss of $776M in fourth quarter 2013

Endo Health Solutions Reports net loss of $776M in fourth quarter 2013

Endo Health Solutions today reported fourth quarter 2013 revenues of $585 million, compared to $750 million for the same quarter of 2012. [More]

Mild LUTS associated with storage symptoms in men

Researchers from Taiwan have found that the International Prostate Symptom Score can differentiate between men with bladder storage dysfunction and those with bladder outlet disorders. [More]

Serum CRP levels linked to LUTS

Research from Taiwan shows that serum C-reactive protein levels are associated with storage lower urinary tract symptoms and sensory bladder disorders. [More]
Findings could improve clinical management of patients with breast tissue abnormalities

Findings could improve clinical management of patients with breast tissue abnormalities

Contrary to existing understanding, long-term follow-up of patients with two types of breast tissue abnormalities suggests that both types of abnormalities have the same potential to progress to breast cancer, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research. Findings from this study could improve clinical management of patients with breast tissue abnormalities. [More]
Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Normally, tissue injury triggers a mechanism in cells that tries to repair damaged tissue and restore the skin to a normal, or homeostatic state. Errors in this process can give rise to various problems, such as chronic inflammation, which is a known cause of certain cancers. [More]
Ceram-lead project to develop new biomaterials and new arterial stents awarded Euro 5.874M by the European Union

Ceram-lead project to develop new biomaterials and new arterial stents awarded Euro 5.874M by the European Union

As co-ordinator of the European project ‘ReBioStent’, Ceram, the international materials technology company, is pleased to announce that the project, to develop new biomaterials and new arterial stents, has been awarded Euro 5.874M by the European Union. [More]

HoLEP effective for overactive bladder symptoms

Research shows that Holmium laser enucleation of the prostate is effective in improving overactive bladder symptoms and urodynamic parameters in men with benign prostatic hyperplasia. [More]
Proteon's PRT-201 gets orphan drug designation for prevention of arteriovenous access dysfunction

Proteon's PRT-201 gets orphan drug designation for prevention of arteriovenous access dysfunction

Proteon Therapeutics, Inc., a privately held biopharmaceutical company developing novel, first-in-class pharmaceuticals to address the critical medical needs of patients with kidney and vascular diseases, today announced that its lead product, PRT-201, has received orphan drug designation in the European Union for the prevention of arteriovenous access dysfunction in hemodialysis patients. [More]
Incision technique shows potential for bladder neck contracture

Incision technique shows potential for bladder neck contracture

A US team reports that deep lateral transurethral incisions are a promising technique for the treatment of recurrent bladder neck contracture in men following prostate surgery. [More]
Nocturia common in Japanese patients

Nocturia common in Japanese patients

Results from an outpatient-based study indicate that nocturia is common among Japanese patients, with men, the elderly, and those with hypertension at the greatest risk. [More]
Screening for genetic mutations may help identify silent carriers of adrenal Cushing's syndrome

Screening for genetic mutations may help identify silent carriers of adrenal Cushing's syndrome

Genetic research that will be published tomorrow in the New England Journal of Medicine suggests to Dr. André Lacroix, professor at the University of Montreal, that clinicians' understanding and treatment of a form of Cushing's syndrome affecting both adrenal glands will be fundamentally changed, and that moreover, it might be appropriate to begin screening for the genetic mutations that cause this form of the disease. [More]
ESBC joins with Athena Breast Health Network to advance personalized breast cancer risk assessment

ESBC joins with Athena Breast Health Network to advance personalized breast cancer risk assessment

Edith Sanford Breast Cancer (ESBC), part of the Sanford Health system based in Sioux Falls, SD, today announced it is partnering with the Athena Breast Health Network, a University of California program, to advance the use of a personalized breast cancer risk assessment. [More]

EU research project seeks to improve care for patients with adrenal and gonadal hormonal imbalances

The Charité - Universitätsmedizin Berlin is now commencing a new EU research project, dsd-LIFE, to improve clinical care in individuals suffering from hormonal disorders of the gonads and adrenals. [More]
New less invasive surgical method paves way for development of efficient anti-obesity therapies

New less invasive surgical method paves way for development of efficient anti-obesity therapies

Bariatric surgeries, such as a gastric bypass, are currently the most effective anti-obesity therapies. They also lead to a reduced insulin resistance. However, the pitfall of these surgical interventions is that they are highly invasive and often permanent procedures. [More]
Psoriasis and the nervous system: an interview with Dr Nicole Ward, Case Western Reserve University

Psoriasis and the nervous system: an interview with Dr Nicole Ward, Case Western Reserve University

The prevalence of skin disease exceeds that of obesity, hypertension or cancer. One in three individuals in the United States suffers with a skin disease, with ~2-3% of the American population suffering from psoriasis. [More]
NeoTract treats first patient in US with UroLift System

NeoTract treats first patient in US with UroLift System

NeoTract, Inc., today announced that the first patient in the United States has been treated with its commercial UroLift System, the first permanent implant to treat symptoms due to urinary outflow obstruction secondary to benign prostatic hyperplasia in men 50 years of age or older. [More]
Basic fibroblast growth factor can protect endplate in motor neurons of injured spinal cord

Basic fibroblast growth factor can protect endplate in motor neurons of injured spinal cord

In current studies, the degeneration and protection measures in the distal end of the injured spinal cord and target organ muscle effector have scarcely been investigated. The distal end of the spinal cord and neuromuscular junction may develop secondary degenera-tion and damage following spinal cord injury because of the loss of neural connections. [More]
Surgery may not be necessary for women with abnormal breast tissue

Surgery may not be necessary for women with abnormal breast tissue

Surgery is not always necessary for women with a type of breast tissue abnormality associated with a higher risk of cancer, according to a new study published online in the journal Radiology. [More]