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Uroflowmetry reflects symptom severity in men with LUTS

Uroflowmetry reflects symptom severity in men with LUTS

Uroflowmetry is valuable for assessing disease severity in men with lower urinary tract symptoms due to benign prostatic hyperplasia, researchers believe. [More]
Study shows prevalence of uterine cancer in women undergoing hysterectomy procedure

Study shows prevalence of uterine cancer in women undergoing hysterectomy procedure

Among women undergoing a minimally invasive hysterectomy using electric power morcellation, uterine cancers were present in 27 per 10,000 women at the time of the procedure, according to a study published by JAMA. [More]
NANOG gene linked to tumours derived from stratified epithelia

NANOG gene linked to tumours derived from stratified epithelia

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia-those that form part of the epidermis of the skin or cover the oesophagus or the vagina-in adult organisms. [More]
Galderma's trifarotene molecule gets FDA Orphan Drug Designation for treatment of congenital ichthyosis

Galderma's trifarotene molecule gets FDA Orphan Drug Designation for treatment of congenital ichthyosis

Galderma announces that the U.S. FDA granted Orphan Drug Designation status for the company's trifarotene molecule for the treatment of congenital ichthyosis. Based on this decision, Galderma plans to implement a clinical development plan, reinforcing its commitment to exploring new treatment options for rare diseases, as well as meeting the needs of all patients with skin diseases over the course of their lives. [More]
Metabolic syndrome components may influence LUTS/BPH

Metabolic syndrome components may influence LUTS/BPH

Abdominal aortic calcification and visceral fat obesity each seem to influence lower urinary tract symptoms in men with benign prostatic hyperplasia, study findings suggest. [More]
Biomarkers help resolve differential diagnosis between MPM and non-cancerous pleural tissue

Biomarkers help resolve differential diagnosis between MPM and non-cancerous pleural tissue

Scientists have identified four biomarkers that may help resolve the difficult differential diagnosis between malignant pleural mesothelioma (MPM) and non-cancerous pleural tissue with reactive mesothelial proliferations (RMPs). [More]
Newborn congenital adrenal hyperplasia screening justified

Newborn congenital adrenal hyperplasia screening justified

The Swedish neonatal screening programme successfully detected all cases of clinically classified salt-wasting congenital adrenal hyperplasia during a 26-year period, researchers report. [More]
FDA approves Trimel’s Natesto nasal gel to treat adult males with low testosterone

FDA approves Trimel’s Natesto nasal gel to treat adult males with low testosterone

Trimel Pharmaceuticals Corporation announced today that the United States Food and Drug Administration (FDA) has approved Natesto (testosterone), formerly CompleoTRT, the first and only testosterone nasal gel for replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone. [More]
Sanofi and Lilly announces agreement to pursue regulatory approval of Cialis

Sanofi and Lilly announces agreement to pursue regulatory approval of Cialis

Sanofi and Eli Lilly and Company today announced an agreement to pursue regulatory approval of nonprescription Cialis (tadalafil). [More]
GSK reports positive results from Incruse Ellipta and Advair Diskus combination therapy in COPD patients

GSK reports positive results from Incruse Ellipta and Advair Diskus combination therapy in COPD patients

GlaxoSmithKline plc today presented data at the American Thoracic Society (ATS) from a late-stage clinical study. [More]
Noninvasive technique detects prostate cancer using an electronic nose

Noninvasive technique detects prostate cancer using an electronic nose

We may soon be able to make easy and early diagnoses of prostate cancer by smell. Investigators in Finland have established that a novel noninvasive technique can detect prostate cancer using an electronic nose. In a proof of principle study, the eNose successfully discriminated between prostate cancer and benign prostatic hyperplasia (BPH) by "sniffing" urine headspace (the space directly above the urine sample). Results using the eNose are comparable to testing prostate specific antigen (PSA), reports the Journal of Urology. [More]
GSK, Theravance announce availability of Anoro Ellipta in the US for COPD treatment

GSK, Theravance announce availability of Anoro Ellipta in the US for COPD treatment

GlaxoSmithKline plc and Theravance, Inc. today announced that Anoro Ellipta (umeclidinium and vilanterol inhalation powder), the first once-daily product approved in the US that combines two long-acting bronchodilators in a single inhaler for the maintenance treatment of chronic obstructive pulmonary disease (COPD), is now available to retail pharmacies in the US. [More]
Researchers discover hotspot L205R mutation is closely associated with adrenocortical tumors

Researchers discover hotspot L205R mutation is closely associated with adrenocortical tumors

Chinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI, and other institutions have discovered that the activating hotspot L205R mutation in PRKACA gene was closely associated with adrenocortical tumors (ACTs), and the relationship of recurrently mutated DOT1L and CLASP2 with ACTs' other subtypes. [More]
Antimuscarinics plus α-blockers ‘recommended for male LUTS’

Antimuscarinics plus α-blockers ‘recommended for male LUTS’

Antimuscarinics “could and should” be used in the pharmacological treatment of men with lower urinary tract symptoms caused by benign prostatic hyperplasia or bladder outlet obstruction, say the authors of a meta-analysis published in Urology. [More]
UL researcher receives €250,000 to investigate Benign Prostatic Hyperplasia

UL researcher receives €250,000 to investigate Benign Prostatic Hyperplasia

University of Limerick researcher, Dr Niall Kelly was recently awarded in the region of €250,000 by the Health Research Board to investigate a condition called Benign Prostatic Hyperplasia (BPH) which affects 50% of men over the age of 50. [More]
Endo Health Solutions Reports net loss of $776M in fourth quarter 2013

Endo Health Solutions Reports net loss of $776M in fourth quarter 2013

Endo Health Solutions today reported fourth quarter 2013 revenues of $585 million, compared to $750 million for the same quarter of 2012. [More]
Mild LUTS associated with storage symptoms in men

Mild LUTS associated with storage symptoms in men

Researchers from Taiwan have found that the International Prostate Symptom Score can differentiate between men with bladder storage dysfunction and those with bladder outlet disorders. [More]

Serum CRP levels linked to LUTS

Research from Taiwan shows that serum C-reactive protein levels are associated with storage lower urinary tract symptoms and sensory bladder disorders. [More]
Findings could improve clinical management of patients with breast tissue abnormalities

Findings could improve clinical management of patients with breast tissue abnormalities

Contrary to existing understanding, long-term follow-up of patients with two types of breast tissue abnormalities suggests that both types of abnormalities have the same potential to progress to breast cancer, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research. Findings from this study could improve clinical management of patients with breast tissue abnormalities. [More]
Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Normally, tissue injury triggers a mechanism in cells that tries to repair damaged tissue and restore the skin to a normal, or homeostatic state. Errors in this process can give rise to various problems, such as chronic inflammation, which is a known cause of certain cancers. [More]