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Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.
Researchers show how microRNAs play key role in tumor progression and response to radiation

Researchers show how microRNAs play key role in tumor progression and response to radiation

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: "I sometimes compare MicroRNA to tweets -- they're short, transient and constantly changing." [More]
Results of high-impact clinical trials could improve kidney-related medical care

Results of high-impact clinical trials could improve kidney-related medical care

The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented at ASN Kidney Week 2016, November 15-20 at McCormick Place in Chicago, IL. [More]
Bilingual support group addressing health needs of lupus patients has positive impact, study finds

Bilingual support group addressing health needs of lupus patients has positive impact, study finds

A bilingual support group addressing the psychological and educational needs of patients with lupus and their families is a valuable resource to help them cope, according to a study at Hospital for Special Surgery. [More]
New Australian research shows how immune system avoids attacking own tissues with antibodies

New Australian research shows how immune system avoids attacking own tissues with antibodies

New Australian research has shown how the immune system avoids attacking its own tissues with antibodies - whilst still maintaining a strong defence against invaders. [More]
FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Amgen today announced that the U.S. Food and Drug Administration has approved the supplemental Biologics License Application for the expanded use of ENBREL (etanercept), making it the first and only systemic therapy to treat pediatric patients (ages 4-17) with chronic moderate-to-severe plaque psoriasis. [More]
New research identifies mechanism that may lead to treatment of fibrosis in scleroderma

New research identifies mechanism that may lead to treatment of fibrosis in scleroderma

The prognosis for patients diagnosed with scleroderma - an autoimmune disease characterized by fibrosis of the skin - is not typically a rosy one. With limited treatment options available, those suffering from the disorder can face disabling hardening and tightening of their skin. [More]
Two leading non-profit organizations sign strategic affiliation to hasten drug development

Two leading non-profit organizations sign strategic affiliation to hasten drug development

The Scripps Research Institute and the California Institute for Biomedical Research - two leading non-profit research organizations - today announced the signing of a strategic affiliation that combines the two organizations into a new biomedical research entity with the tools and know-how to rapidly translate its scientific discoveries into life-saving medicines for the public benefit. [More]
Novel biomarkers enhance power to predict therapeutic efficacy in LN prognostic models

Novel biomarkers enhance power to predict therapeutic efficacy in LN prognostic models

Results of preclinical studies by investigators at the Medical University of South Carolina reported in the August 2016 issue of Arthritis & Rheumatology demonstrate for the first time that including novel biomarkers in lupus nephritis (LN) prognostic models significantly increases their power to predict therapeutic efficacy. [More]
DHA intake can prevent known trigger of lupus, study finds

DHA intake can prevent known trigger of lupus, study finds

A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders. [More]
Study suggests interactions between distant DNA regions may impact disease gene levels

Study suggests interactions between distant DNA regions may impact disease gene levels

A person's DNA sequence can provide a lot of information about how genes are turned on and off, but new research out of Case Western Reserve University School of Medicine suggests the 3-D structure DNA forms as it crams into cells may provide an additional layer of gene control. [More]
Researchers uncover specific sites in the genome linked to high blood pressure

Researchers uncover specific sites in the genome linked to high blood pressure

Three large, collaborating international consortia of researchers, including a team co-led by investigators from Brigham and Women's Hospital, have uncovered new genes and sites in the genome tied to elevated blood pressure, implicating certain biological pathways and pointing toward new therapeutic strategies for treating hypertension. [More]
Enhanced communication and coordination of care can provide health benefits for lupus patients

Enhanced communication and coordination of care can provide health benefits for lupus patients

Results from a recent study suggest that improved communication and coordination of care between patients, physicians, and health insurers can provide important health benefits for patients with lupus. [More]
Mice study finds new approach to halt cycle of chronic inflammation in lupus

Mice study finds new approach to halt cycle of chronic inflammation in lupus

Molecules that scavenge debris from dying cells appear to halt the cycle of chronic inflammation in lupus, while also enhancing the body's ability to combat flu, according to Duke Health studies in mice. [More]
Drug for boosting immune system shows promise as potential new treatment for lupus

Drug for boosting immune system shows promise as potential new treatment for lupus

A drug originally used to boost the immune system is showing promise as a potential new treatment for lupus, Monash University-led research published today (August 9) shows. Lupus is an autoimmune disease, where the immune system attacks the body's own organs and tissues. [More]
TSRI study unveils new twist in immune biology

TSRI study unveils new twist in immune biology

A new study, led by scientists at The Scripps Research Institute, reveals a surprising twist in immune biology. [More]
New research opens door to influencing immune system

New research opens door to influencing immune system

A new international collaboration involving scientists at The Scripps Research Institute opens a door to influencing the immune system, which would be useful to boost the effectiveness of vaccines or to counter autoimmune diseases such as lupus and rheumatoid arthritis. [More]
Researchers identify key immune differences that could help in development of effective HIV vaccine

Researchers identify key immune differences that could help in development of effective HIV vaccine

One of the main mysteries confounding development of an HIV vaccine is why some people infected with the virus make the desired antibodies after several years, but a vaccine can't seem to induce the same response. [More]
Researchers demonstrate important functional role of lincRNA in immune system

Researchers demonstrate important functional role of lincRNA in immune system

A long non-coding RNA (lincRNA) - called lincRNA-EPS - responsible for regulating innate immunity has been identified by a team of scientists at the University of Massachusetts Medical School. [More]
High frequency of alleles could increase risk of lupus in non-Europeans

High frequency of alleles could increase risk of lupus in non-Europeans

Non-Europeans have a higher frequency of the gene variants that increase the risk of lupus as compared to the European population, a new study from researchers at the National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' and King's College London, has confirmed. [More]
BU researcher receives grant to better understand breast cancer in African-American women

BU researcher receives grant to better understand breast cancer in African-American women

Why do African-American women die at a higher rate and experience more aggressive breast tumors than white women? Researchers from Boston University's Slone Epidemiology Center (SEC) have received funding from the National Cancer Institute to explore this question. [More]
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