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Systemic lupus erythematosus (SLE), also called lupus, is an autoimmune disorder characterized by the immune system attacking the body's own tissues and organs, leading to inflammation and damage. The severity of the disease varies, from mild cases only involving the skin to severe cases affecting multiple organs, including the brain. Lupus sufferers experience flares, or intervals of active disease, and remissions in disease. The disease most predominantly occurs in women of childbearing age, but also affects children, adolescents, and men. While the cause of lupus is still unknown, various genetic, environmental, and infectious causes have been associated with its development. Current treatments for lupus vary depending on the extent of the disease, and may change over time. Some medications used to ease symptoms include nonsteroidal anti-inflammatory drugs, antimalarial drugs, corticosteroids, and immunosuppressive medications, though many of these drugs carry their own risks.
SBP scientists discover new regulator of immune responses

SBP scientists discover new regulator of immune responses

Research led by scientists at the Sanford Burnham Prebys Medical Discovery Institute has identified a new regulator of immune responses. The study, published recently in Immunity, sheds new light on why T cells fail to clear chronic infections and eliminate tumors. [More]
Personalized DXM-loaded leukosomes may help treat inflammation

Personalized DXM-loaded leukosomes may help treat inflammation

Nanosized Trojan horses created from a patient's own immune cells have successfully treated inflammation by overcoming the body's complex defense mechanisms, perhaps leading to broader applications for treating diseases characterized by inflammation, such as cancer and cardiovascular diseases. [More]
Study shows inhibition of SHP-2 enzyme can diminish lupus symptoms

Study shows inhibition of SHP-2 enzyme can diminish lupus symptoms

Researchers at Beth Israel Deaconess Medical Center have identified an enzyme that is significantly elevated in mouse models of systemic lupus erythematosus and in blood samples of patients with lupus. [More]
New BSR report sets roadmap to enhance care for individuals with rare rheumatic and musculoskeletal conditions

New BSR report sets roadmap to enhance care for individuals with rare rheumatic and musculoskeletal conditions

The British Society for Rheumatology has today launched a report setting out a programme of work to enhance care for people with rare rheumatic and musculoskeletal conditions. [More]
Caltech researchers discover new potential cause for Crohn's disease

Caltech researchers discover new potential cause for Crohn's disease

The community of beneficial bacteria that live in our intestines, known as the gut microbiome, are important for the development and function of the immune system. There has been growing evidence that certain probiotics--therapies that introduce beneficial bacteria into the gut--may help alleviate some of the symptoms of intestinal disorders such as Crohn's disease. [More]
CSL362 antibody targets, depletes pDCs and other cells implicated in SLE

CSL362 antibody targets, depletes pDCs and other cells implicated in SLE

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Autoantibodies, which are produced by B cells, contribute to development of SLE. [More]
Enzyme previously thought beneficial could pose threat to developing embryos

Enzyme previously thought beneficial could pose threat to developing embryos

A pair of Oklahoma Medical Research Foundation scientists have discovered that an enzyme previously thought only to be beneficial could, in fact, pose significant danger to developing embryos. The new research could have implications not only for prenatal development but also for treating lymphedema and liver damage resulting from acetaminophen overdose. [More]
Certain sugars in the body play key role in colitis, colon cancer development

Certain sugars in the body play key role in colitis, colon cancer development

An Oklahoma Medical Research Foundation scientist has discovered that certain sugars produced by the body play an important role in the development of colitis and, ultimately, colon cancer. The new finding could potentially lead to therapies for ulcerative colitis, Crohn's disease and colon cancer. [More]
LJI study could provide important target for autoimmune disease interventions

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones. [More]
Rapamycin drug could target neural damage linked to Leigh syndrome

Rapamycin drug could target neural damage linked to Leigh syndrome

Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug--called rapamycin--prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy. [More]
Newly published manuscripts enhance understanding of the immune system

Newly published manuscripts enhance understanding of the immune system

MedImmune, the global biologics research and development arm of AstraZeneca, today announced that it has achieved a significant scientific milestone by publishing three manuscripts in Nature Immunology that advance the understanding of the immune system and highlight underlying mechanisms in two little-understood disease areas -- chronic obstructive pulmonary disease (COPD) and systemic lupus erythematosus (SLE). [More]
LAP defects may lead to lupus-like autoimmune disorder

LAP defects may lead to lupus-like autoimmune disorder

A casual observation about size differences in mice has led to the discovery that defects in a process for digesting dead cells called LC3-associated phagocytosis (LAP) may lead to a lupus-like autoimmune disorder. St. Jude Children's Research Hospital scientists led the research, which appears as an advance online publication today in the scientific journal Nature. [More]
Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response. [More]
Intestinal bacteria can be used to reduce cancer risk, reveals UCLA study

Intestinal bacteria can be used to reduce cancer risk, reveals UCLA study

Researchers have shown that various types of intestinal bacteria might be factors in both causing and preventing obesity, and in other conditions and diseases. Now, a UCLA study suggests that it could also potentially be used to reduce the risk for some types of cancer. [More]
Cell-signaling protein holds key to understanding autoantibody formation in lupus patients

Cell-signaling protein holds key to understanding autoantibody formation in lupus patients

A signaling molecule called interferon gamma could hold the key to understanding how harmful autoantibodies form in lupus patients. The finding could lead to new treatments for the chronic autoimmune disease, said researchers at Penn State College of Medicine. [More]
Inflectra (infliximab-dyyb) approved for multiple indications

Inflectra (infliximab-dyyb) approved for multiple indications

The U.S. Food and Drug Administration today approved Inflectra (infliximab-dyyb) for multiple indications. Inflectra is administered by intravenous infusion. This is the second biosimilar approved by the FDA. [More]
Researchers use DNA sequencing technology to identify gene variants that affect susceptibility to SLE

Researchers use DNA sequencing technology to identify gene variants that affect susceptibility to SLE

Demonstrating the potential of precision medicine, an international study based at UT Southwestern Medical Center used next-generation DNA sequencing technology to identify more than 1,000 gene variants that affect susceptibility to systemic lupus erythematosus (SLE). [More]
Xencor begins XmAb5871 Phase 2 trials in patients with IgG4-RD and Systemic Lupus Erythematosus

Xencor begins XmAb5871 Phase 2 trials in patients with IgG4-RD and Systemic Lupus Erythematosus

Xencor, Inc., a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of autoimmune diseases, asthma and allergic diseases and cancer, today announced dosing the first patient in a Phase 2 trial of XmAb5871 in patients with IgG4-Related Disease (IgG4-RD). [More]
Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage. [More]
Influenza virus can able to circumvent the body's immune system

Influenza virus can able to circumvent the body's immune system

Influenza is able to mask itself, so that the virus is not initially detected by our immune system. This is the result of new research from Aarhus University. The researchers behind the study hope that the discovery can be used to develop better treatment against influenza and chronic inflammation conditions such as rheumatoid arthritis. [More]
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