Multiple Sclerosis News and Research RSS Feed - Multiple Sclerosis News and Research

Multiple sclerosis (MS) is a severe autoimmune disease of the central nervous system that affects the brain and spinal cord, causing problems with muscle movement, balance and vision.

In MS, the protein coating called myelin, which protects nerves and helps electrical signals travel from the brain to the rest of the body, is damaged. The immune system, which usually fights infection, mistakes myelin for a foreign body and attacks it, stripping it from around the nerves. Exactly what causes this abnormal immune response is unclear, but research suggests a combination of both genetic and environmental factors.

The damaged myelin disrupts the transfer of nerve signals which may slow down, become distorted or stop altogether. This can cause severe symptoms ranging from vision loss through to muscle stiffness, loss of control over muscle movement, difficulties with balance and poor co-ordination.

Around 100,000 people in the UK have MS and it affects about three times as many women as men. The usual age at which diagnosis occurs is around 30, however, symptoms often first develop between the ages of 15 and 45.

Currently, there is no cure for MS but therapeutic approaches such as physiotherapy and steroid injections are used to manage the condition and ease symptoms.
Two statistically significant genetic variants may be linked to increased PTSD risk in veterans

Two statistically significant genetic variants may be linked to increased PTSD risk in veterans

In a massive analysis of DNA samples from more than 13,000 U.S. soldiers, scientists have identified two statistically significant genetic variants that may be associated with an increased risk of post-traumatic stress disorder (PTSD), an often serious mental illness linked to earlier exposure to a traumatic event, such as combat and an act of violence. [More]
MNI scientists move a step forward in efforts to treat hereditary spastic paraplegia

MNI scientists move a step forward in efforts to treat hereditary spastic paraplegia

Scientists at the Montreal Neurological Institute and Hospital have identified novel gene mutations that cause hereditary spastic paraplegia (HSP), a step forward in efforts to treat this debilitating disease. [More]
Scientists use non-invasive way to track rapid myelination of nerve fibers in children's brains

Scientists use non-invasive way to track rapid myelination of nerve fibers in children's brains

Much like electricity traveling down wires, nerve impulses in our brain travel along nerve fibers. And just as wires need insulation to function well, nerve fibers, too, rely on a kind of insulation called myelin, a fatty substance that protects them and increases the speed at which nerve impulses travel. [More]
Real risk of rebound syndrome following fingolimod cessation for MS

Real risk of rebound syndrome following fingolimod cessation for MS

Rebound syndrome following cessation of fingolimod for multiple sclerosis occurs at a clinically relevant rate, shows research, prompting the need for further study on how best to sequence and discontinue such drugs. [More]
Yoga, aquatic exercise have positive influence on multiple sclerosis symptoms

Yoga, aquatic exercise have positive influence on multiple sclerosis symptoms

Exercise can have a positive influence on certain symptoms of multiple sclerosis: Patients who do yoga and aquatic exercise suffer less from fatigue, depression and paresthesia, as reported by researchers from the University of Basel and the Psychiatric University Clinics Basel in a joint study with colleagues in Iran. [More]
LJI study could provide important target for autoimmune disease interventions

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones. [More]
Safety tips to prevent slips and falls among seniors

Safety tips to prevent slips and falls among seniors

May is National Trauma Awareness Month, and this year the American Trauma Society is raising awareness about senior safety and falls with "Safe Steps for Seniors." The Stony Brook Trauma Center is taking steps to shed light on the matter to help prevent serious injuries from occurring. [More]
Study examines benefits of exercise, behavioral therapy in MS patients

Study examines benefits of exercise, behavioral therapy in MS patients

Groundhog Day 1994 is one Linda Friedrich will never forget. That's the day a neurologist told her, "You have multiple sclerosis and there's nothing we can do." [More]
People with TBI may have long-term sleep disturbances

People with TBI may have long-term sleep disturbances

People who have had a traumatic brain injury (TBI) may still have sleep problems a year and a half after being injured, according to a study published in the April 27, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. In addition, people with TBI may also be unaware of just how much their sleep is disturbed. [More]
RADAR-CNS programme aims to improve lives of patients with brain disorders

RADAR-CNS programme aims to improve lives of patients with brain disorders

A major new research program supported by the Innovative Medicines Initiative launches today, which will develop new ways of monitoring major depressive disorder, epilepsy, and multiple sclerosis using wearable devices and smartphone technology. [More]
New method measures LCO in person's standing posture to diagnose neuromuscular disorders

New method measures LCO in person's standing posture to diagnose neuromuscular disorders

A new technique might be used to diagnose neuromuscular disorders such as multiple sclerosis or impairment from concussions by detecting and measuring subtle oscillations in a person's standing posture. [More]
Innovations in pre-clinical MRI: an interview with Priv. Doz. Dr. Dominik von Elverfeldt

Innovations in pre-clinical MRI: an interview with Priv. Doz. Dr. Dominik von Elverfeldt

To me the most exciting aspect of pre-clinical imaging is its broad range, from very basic science up to applied science. You deal with a range of disciplines including biology, chemistry, physics, biochemistry, biophysics, cell biology and of course medicine, as the aim is the translation of research to humans. [More]
Rituximab outperforms fingolimod after natalizumab switch

Rituximab outperforms fingolimod after natalizumab switch

Rituximab is more effective and better tolerated than fingolimod for patients with multiple sclerosis needing to switch from natalizumab due to JC-virus antibody positivity, research suggests. [More]
Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

The recent survey you ask about was conducted by the MS Trust in 2012. It revealed that nearly one fifth of respondents had seen neither an MS specialist nurse (MSSN) nor a neurologist in the past year, and so will not have received the comprehensive annual review recommended by the National Institute for Health and Care Excellence (NICE). [More]
Rituximab drug more effective than fingolimod for patients with highly active multiple sclerosis

Rituximab drug more effective than fingolimod for patients with highly active multiple sclerosis

A new study indicates that rituximab is more effective than fingolimod for preventing relapses in patients with highly active multiple sclerosis switching from treatment with natalizumab. [More]
Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Specific combinations of gut bacteria produce substances that affect myelin content and cause social avoidance behaviors in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal eLife. This research suggests that targeting intestinal bacteria, or their metabolites, could be one way to treat debilitating psychiatric disorders and demyelinating diseases, like multiple sclerosis. [More]
Study aims to determine how aches, pains before and after concussion play role in recovery

Study aims to determine how aches, pains before and after concussion play role in recovery

Athletes who have medical complaints, like aches and pains, that have no known physical cause may take longer to recover after a concussion, according to a study published in the April 20, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
TNF-alpha protein involved in autoimmune diseases may also promote tissue healing

TNF-alpha protein involved in autoimmune diseases may also promote tissue healing

As its name suggests, inflammatory bowel disease, which afflicts more than 1.6 million Americans, involves chronic inflammation of all or some of the digestive tract. An autoimmune disease known to have a strong genetic component, its symptoms are abdominal cramps, bloody diarrhea, and fever and, sometimes, weight loss. IBD, which is a group of inflammatory conditions, includes Crohn's disease and ulcerative colitis. [More]
Novel method could help analyze GWAS results for sporadic diseases

Novel method could help analyze GWAS results for sporadic diseases

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome-wide association studies can contribute to sporadic Parkinson's disease (PD). The approach could be used to analyze GWAS results for other sporadic diseases with genetic causes, such as multiple sclerosis, diabetes, and cancer. [More]
AAN’s updated guideline on botulinum toxin use covers four neurologic disorders

AAN’s updated guideline on botulinum toxin use covers four neurologic disorders

The American Academy of Neurology has updated its 2008 guidelines on the use of botulinum toxin for spasticity, cervical dystonia, blepharospasm and migraine headache, based on recent research. [More]
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