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MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's

MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's

Although a family history of Alzheimer's disease is a primary risk factor for the devastating neurological disorder, mutations in only three genes - the amyloid precursor protein and presenilins 1 and 2 - have been established as causative for inherited, early-onset Alzheimer's, accounting for about half of such cases. [More]

Final results of PUFs clinical study of Covidien's Pipeline device published in June issue of Radiology

Covidien, a leading global provider of healthcare products, today announced that the final results of the PUFs (Pipeline for Uncoilable or Failed Aneurysms) clinical study of its Pipeline embolization device have been published in the June issue of Radiology. [More]
Anatomy of a Hospital: New book chronicles history of nation's oldest hospital for orthopedics

Anatomy of a Hospital: New book chronicles history of nation's oldest hospital for orthopedics

With 537 pages and 150 photographs, "Anatomy of a Hospital" chronicles the history of the nation's oldest hospital for orthopedics, from its beginnings in a doctor's home to help destitute children with disabilities to the premier hospital it has become today. [More]

Hospitalized patients do not receive blood thinners to prevent blood clots, researchers report

Researchers at Johns Hopkins report that hospitalized patients do not receive more than one in 10 doses of doctor-ordered blood thinners prescribed to prevent potentially lethal or disabling blood clots, a decision they say may be fueled by misguided concern by patients and their caregivers. [More]
UTHealth psychiatrists win 2013 American Psychiatric Association's Mind Games competition for the third time

UTHealth psychiatrists win 2013 American Psychiatric Association's Mind Games competition for the third time

For the final question in the 2013 American Psychiatric Association's Mind Games competition, it was not enough to name the medication (ketamine) that has been shown in a few small studies to have a rapid antidepressant effect in treatment refractory patients. [More]
Study offers hope for development of novel treatments for stroke, neurological diseases

Study offers hope for development of novel treatments for stroke, neurological diseases

A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers. [More]

Scientists measure major difference between brains of patients with Alzheimer's disease and healthy family members

Scientists at Washington University School of Medicine in St. Louis have measured a significant and potentially pivotal difference between the brains of patients with an inherited form of Alzheimer's disease and healthy family members who do not carry a mutation for the disease. [More]
Research reveals that men who experience RLS may have higher risk of dying earlier

Research reveals that men who experience RLS may have higher risk of dying earlier

Men who experience restless legs syndrome may have a higher risk of dying earlier, according to research that appears in the June 12, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Common medications reduce brain plaques in mice

Common medications reduce brain plaques in mice

Multiple drug classes commonly prescribed for common medical conditions are capable of influencing the onset and progression of Alzheimer's disease, according to researchers at The Mount Sinai Medical Center. The findings are published online in the journal PLoS One. [More]
Hypometabolism in brain regions of cognitively normal patients associated with Alzheimer's disease

Hypometabolism in brain regions of cognitively normal patients associated with Alzheimer's disease

Alzheimer's disease has been linked in many studies to amyloid plaque buildup in the brain, but new research is finding a common thread between amyloid burden and lower energy levels, or metabolism, of neurons in certain areas of the brain associated with Alzheimer's disease-even for people with no sign of cognitive decline. [More]
UCSF Benioff Children's Hospital earns top ranking

UCSF Benioff Children's Hospital earns top ranking

UCSF Benioff Children's Hospital ranks among the nation's best children's hospitals in nine specialties and is one of the top-ranked centers in California, according to the 2013-14 Best Children's Hospitals survey conducted by the U.S. News Media Group. [More]
C.S. Mott Children's Hospital ranked among nation's best children's hospitals

C.S. Mott Children's Hospital ranked among nation's best children's hospitals

The University of Michigan's C.S. Mott Children's Hospital is among the best children's hospitals in the country in pediatric specialties and is the only hospital in Michigan ranked in all 10 specialties evaluated, according to the U.S. News & World Report's 2013-14 Best Children's Hospitals rankings. [More]
Two studies shed light on joint replacement outcomes in rheumatoid arthritis patients

Two studies shed light on joint replacement outcomes in rheumatoid arthritis patients

Two new studies by researchers at Hospital for Special Surgery have shed light on joint replacement outcomes in patients with rheumatoid arthritis. One study overturns the common belief that RA patients have worse outcomes after a total knee replacement than patients who undergo the operation for osteoarthritis. The other study demonstrates that RA patients who undergo a total hip replacement were as likely to have significant improvements in function and pain as patients with osteoarthritis, even though they did not do as well. [More]
Johns Hopkins researchers develop experimental vaccine for TB meningitis

Johns Hopkins researchers develop experimental vaccine for TB meningitis

A team of Johns Hopkins researchers working with animals has developed a vaccine that prevents the virulent TB bacterium from invading the brain and causing the highly lethal condition TB meningitis, a disease that disproportionately occurs in TB-infected children and in adults with compromised immune system. [More]

UC Irvine researchers to study how maternal signals and care impact adolescent cognitive behaviors

With $10 million in new federal funding, UC Irvine researchers will study how maternal signals and care before and after birth may increase an infant's vulnerability to adolescent cognitive and emotional problems, such as risky behaviors, addiction and depression. [More]
Nimodipine reduces febrile seizures

Nimodipine reduces febrile seizures

Fever-induced childhood seizures, known as febrile seizures, can be terrifying for parents to witness. The full-body convulsions, which mostly affect children six months to five years old, can last from mere seconds up to more than 40 minutes. Currently, children are not treated with daily anticonvulsant medication to prevent these seizures even when they recur repeatedly because toxic side effects of existing treatments outweigh potential benefits. [More]
New weapon in the fight against childhood brain cancer emerges

New weapon in the fight against childhood brain cancer emerges

A relatively new weapon in the fight against childhood brain cancer has emerged that improves upon standard magnetic resonance imaging by providing information about tumor metabolism and extent of cancer in children diagnosed with glioma, a growth caused by the abnormal division of glial cells in the brain, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting. [More]
Vertical Pharmaceuticals, Nautilus Neurosciences sign co-promotion agreement for Lorzone

Vertical Pharmaceuticals, Nautilus Neurosciences sign co-promotion agreement for Lorzone

Vertical Pharmaceuticals, Inc. today announced that Vertical and Nautilus Neurosciences have entered into a co-promotion agreement for Lorzone (chlorzoxazone tablets, USP), a safe, effective, and fast-acting muscle relaxant that is not associated with significant sedation or drowsiness. [More]
Brain circuits involved in compulsive behavior reveal a surprising connection with obesity

Brain circuits involved in compulsive behavior reveal a surprising connection with obesity

What started as an experiment to probe brain circuits involved in compulsive behavior has revealed a surprising connection with obesity. [More]

Stroke experts discuss benefits of endovascular therapy in treating acute ischemic stroke

Covidien, a leading global provider of healthcare products, recently brought together six of the world's prominent thought-leaders in stroke at the 2013 European Stroke Conference. [More]