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Scientists uncover role of HTRA3 protease in Cockayne syndrome

Scientists uncover role of HTRA3 protease in Cockayne syndrome

Scientists from the Institut Pasteur and CNRS, in collaboration with scientists from the Institut Gustave Roussy and CEA, have succeeded in restoring normal activity in cells isolated from patients with the premature aging disease Cockayne syndrome. They have uncovered the role played in these cells by an enzyme, the HTRA3 protease. [More]
Breakthrough in fight against rare kidney disease - Membranous Nephropathy

Breakthrough in fight against rare kidney disease - Membranous Nephropathy

Scientists at The University of Manchester and Central Manchester University Hospitals NHS Foundation Trust have made a significant breakthrough in the fight against Membranous Nephropathy (MN) - a rare kidney disease which can lead to kidney failure. [More]
Omeros receives EMA CHMP positive opinion for Omidria for cataract, IOL replacement surgery

Omeros receives EMA CHMP positive opinion for Omidria for cataract, IOL replacement surgery

Omeros Corporation, a biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for both large-market as well as orphan indications targeting inflammation, coagulopathies and disorders of the central nervous system, today announced that the European Medicines Agency's (EMA's) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for Omidria® (phenylephrine and ketorolac injection) 1%/0.3%. [More]
LSDF awards $2.9 million in funding to help commercialize major medical breakthroughs

LSDF awards $2.9 million in funding to help commercialize major medical breakthroughs

Celiac disease-safe wheat, premature infant pain detection, and new medicines to fight flu and cancer are among the ideas to receive $2.9 million in funding from Washington's Life Sciences Discovery Fund (LSDF). [More]
Splicing pattern of obesity, type 2 diabetes genes may contribute to pathophysiology of obesity

Splicing pattern of obesity, type 2 diabetes genes may contribute to pathophysiology of obesity

Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research from the University of Eastern Finland. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. [More]
Certain proteins may slow cognitive decline in people with Alzheimer's disease

Certain proteins may slow cognitive decline in people with Alzheimer's disease

Certain proteins may slow the devastating memory loss caused by Alzheimer's disease, according to a groundbreaking Iowa State University study. [More]
Nanoparticle-based therapy effective in treating mice with multiple myeloma

Nanoparticle-based therapy effective in treating mice with multiple myeloma

Researchers have designed a nanoparticle-based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow. [More]
Genocea reports positive results from GEN-003 Phase 2 clinical trial for treatment of genital herpes

Genocea reports positive results from GEN-003 Phase 2 clinical trial for treatment of genital herpes

Genocea Biosciences, Inc., a biopharmaceutical company developing T cell-directed vaccines and immunotherapies, today announced positive top-line data from a Phase 2 dose optimization trial evaluating GEN-003 for the treatment of genital herpes. [More]
Second-generation antibiotic shows promise against common bacterial infections

Second-generation antibiotic shows promise against common bacterial infections

Researchers led by St. Jude Children's Research Hospital scientists have developed a second-generation antibiotic that shows early effectiveness against common bacterial infections that pose a serious health threat to children and adults. [More]
RepliCel's autologous cell treatment for Achilles tendinosis to be presented at ISCT 2015

RepliCel's autologous cell treatment for Achilles tendinosis to be presented at ISCT 2015

RepliCel Life Sciences Inc., a clinical stage regenerative medicine company focused on the development of autologous cell therapies, announced today an upcoming poster presentation at the International Society for Cellular Therapy on RepliCel's autologous cell treatment for chronic Achilles tendinosis currently in a Phase 1/2 clinical trial. [More]
Novel drug target identified for treating rheumatoid arthritis

Novel drug target identified for treating rheumatoid arthritis

Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints. [More]
Researchers find that blocking MCAM molecule could slow progression of multiple sclerosis

Researchers find that blocking MCAM molecule could slow progression of multiple sclerosis

A drug that could halt the progression of multiple sclerosis may soon be developed thanks to a discovery by a team at the CHUM Research Centre and the University of Montreal. The researchers have identified a molecule called MCAM, and they have shown that blocking this molecule could delay the onset of the disease and significantly slow its progression. [More]
Non-coding micro RNA molecule may control chemotherapy resistance among ovarian cancer patients

Non-coding micro RNA molecule may control chemotherapy resistance among ovarian cancer patients

A molecule that helps control gene expression may play a role in controlling chemotherapy resistance among patients with the most common form of ovarian cancer. [More]
Available research does not support link between chronic traumatic encephalopathy and sports

Available research does not support link between chronic traumatic encephalopathy and sports

Available research does not support the contention that athletes are uniquely at risk of chronic traumatic encephalopathy (CTE) or other neurodegenerative disorders, according to a review in the June issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. [More]
Kidney function plays critical role in sepsis patients

Kidney function plays critical role in sepsis patients

Researchers at Duke Medicine have determined that kidney function plays a critical role in the fate of patients being treated for sepsis, a potentially life-threatening complication of an infection. [More]
Research may offer new targets for diagnosing, treating advanced prostate cancer

Research may offer new targets for diagnosing, treating advanced prostate cancer

Researchers with the Indiana University School of Medicine have identified a molecule that promotes metastasis of advanced prostate cancer to the bone, an incurable condition that significantly decreases quality of life. [More]
Research shows how immune system controls biological clock in times of inflammation, infection

Research shows how immune system controls biological clock in times of inflammation, infection

Researchers at Trinity College Dublin and the University of Pennsylvania have uncovered an important link between our body clock and the immune system that will have relevance to the treatment of inflammatory and infectious diseases. [More]
New microscopy technique helps researchers to selectively visualize individual cells in living organism

New microscopy technique helps researchers to selectively visualize individual cells in living organism

Researchers at ETH Zurich's Department of Biosystems Science and Engineering in Basel have developed a new microscopy technique that enables for the first time to selectively visualize individual cells within the complex, three-dimensional tissue of a living organism. [More]
Changes in cell membrane play pivotal role in how HCV replicates

Changes in cell membrane play pivotal role in how HCV replicates

New research from the University of Southampton has identified how changes in the cell membrane play a pivotal role in how the Hepatitis C virus replicates. [More]
New research points to potential therapeutic target for treating multiple sclerosis

New research points to potential therapeutic target for treating multiple sclerosis

New research into the causes of the excessive inflammation that drives multiple sclerosis has identified a faulty "brake" within immune cells, a brake that should be controlling the inflammation. This points to a potential target for developing new therapies to treat multiple sclerosis and could have important implications for other autoimmune diseases, such as the colon disease colitis and the chronic skin condition atopic dermatitis. [More]
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