Utilize the PhysioMimix Multi-chip Barrier plate to create more physiologically accurate human gut, or lung barrier models in vitro.
Primary human cells can be cocultured on the basolateral and apical sides of Transwell® inserts within the plates to replicate biological barrier models.
Utilize the plates to cultivate endothelial and epithelial cells in the presence of a media or at the air-liquid interface (ALI). Within each of the 12 chips on the plate, circular flow perfusion on the basolateral side replicates a physiologically appropriate microenvironment.
Compared to static cultures, perfusion enables the formation of 3D-like biological barrier tissue with more in vivo representative shape and integrity while facilitating continuous access to oxygen and nutrients for long-term culture.
These plates work with and accommodate standard 0.33 cm2 Transwell inserts:
- Primary cells
- Induced-pluripotent stem cells
- Immortalized cell lines
- Circulating immune cells
- Organoids
- Commercial inserts (such as MucilAir® or EpiSkin®)
Image Credit: CN-Bio
Barrier plates have a range of uses and are intended to be utilized with PhysioMimix OOC systems.
PhysioMimix Barrier model applications
- COVID 19
- Immune-mediated toxicity
- Drug absorption
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