TNFs and TNFRs: Important regulators of the immune system

Tumor necrosis factors (TNFs) and their corresponding receptors (TNFRs) play crucial roles in regulating the immune system. Dysregulation of TNFs/TNFRs is closely linked to tumorigenesis, progression, invasion, and metastasis. Thus, there has been an upsurge of interest in targeting TNFs/TNFRs for cancer immunotherapy in recent years.

The FDA has approved five medicines that target BCMA for myeloma as of January 2024. An antibody-drug conjugate (ADC) targeting CD30, Brentuximab vedotin, has also been approved by the FDA to specifically target mesenchymal large-cell lymphoma and Hodgkin's lymphoma. 

TNFs also frequently target TNFRs such as 4-1BB, Fas/CD95, and GITR, while other targets include RANKL, TRAIL, BLys, and CD40L. Drugs that target these TNFs/TNFRs are either authorized for clinical use already or are undergoing clinical trials.

Sino Biological offers a comprehensive selection of recombinant TNF and TNFR proteins and corresponding antibodies that support drug discovery and development research on TNFs/TNFRs.

TNF receptor superfamily targeted therapy in cancer

TNFRSF molecules and ligands are targeted on cells of the immune system to boost immune activity against a tumor cell or on tumor cells to either directly promote apoptotic cell death or focus cytotoxic mechanisms toward a tumor cell.

TNFs and TNFRs: Important regulators of the immune system

Image Credit: Sino Biological Inc.

Featured recombinant TNF and TNFR proteins

Human TNF-alpha protein

SPR assay: Captured Adalimumab on Anti-human IgG Fc via CM5 Chip binds to TNF-α with an affinity constant of 0.2843 nM.

SPR assay: Captured Adalimumab on Anti-human IgG Fc via CM5 Chip binds to TNF-α with an affinity constant of 0.2843 nM. Image Credit: Sino Biological Inc.

Human RANKL/TNFSF11 protein

SEC-MALS-validated: The purity was more than 90% and the molecular weight is around 74.5 kDa (Routinely tested).

SEC-MALS-validated: The purity was more than 90% and the molecular weight is around 74.5 kDa (Routinely tested). Image Credit: Sino Biological Inc.

Human BCMA protein

ELISA: Immobilized human TNFRSF17/BCMA protein can bind human Fc-BAFF/Biotin protein (Cat#: 10056-H01H).

ELISA: Immobilized human TNFRSF17/BCMA protein can bind human Fc-BAFF/Biotin protein (Cat#: 10056-H01H). Image Credit: Sino Biological Inc.

Human 4-1BB/CD137 protein

ELISA: Immobilized human 4-1BB-His protein can bind human 4-1BBL-hFc protein (Cat#: 15693-H01H).

ELISA: Immobilized human 4-1BB-His protein can bind human 4-1BBL-hFc protein (Cat#: 15693-H01H). Image Credit: Sino Biological Inc. 

Featured TNF and TNFR antibodies

CD120a/TNFRSF1A neutralizing antibody

Cat#: 10872-R111

Applications

  • Neutralization

Human TNFRSF1A monoclonal antibody neutralizes human TNFα activity induced by human TNFRSF1A.

Human TNFRSF1A monoclonal antibody neutralizes human TNFα activity induced by human TNFRSF1A. Image Credit: Sino Biological Inc.

Anti-TNF-alpha antibody, rabbit mAb

Cat#: 10602-R101

Applications

  • FCM

Flow cytometric analysis of Human TNF-α expression on human peripheral blood lymphocytes.

Flow cytometric analysis of Human TNF-α expression on human peripheral blood lymphocytes. Image Credit: Sino Biological Inc.

More TNF and TNFR products

  • TNF-α
  • CD40L
  • OX40L
  • CD70/CD27L
  • RANKL
  • 4-1BBL
  • LIGHT
  • CD120a/b
  • CD40
  • OX40
  • CD27
  • RANK
  • 4-1BB/CD137
  • HVEM

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