Non-selective agents
- Alprenolol
- Bucindolol
- Carteolol
- Carvedilol (has additional α-blocking activity)
- Labetalol (has additional α-blocking activity)
- Nadolol
- Penbutolol (has intrinsic sympathomimetic activity)
- Pindolol (has intrinsic sympathomimetic activity)
- Propranolol
- Timolol
β1-Selective agents
- Acebutolol (has intrinsic sympathomimetic activity)
- Atenolol
- Betaxolol
- Bisoprolol
- Celiprolol
- Esmolol
- Metoprolol
- Nebivolol
β2-Selective agents
- Butaxamine (weak α-adrenergic agonist activity) - No common clinical applications, but used in experiments.
- ICI-118 Highly selective β2-adrenergic receptor antagonist - No known clinical applications, but used in experiments due to its strong receptor specificity.
Comparative Information
Pharmacological differences
- Agents with intrinsic sympathomimetic action (ISA)
- Acebutolol, carteolol, celiprolol, mepindolol, oxprenolol,
pindolol
- Agents with greater aqueous solubility
- , celiprolol, nadolol, sotalol
- Agents with membrane stabilizing effect
- Acebutolol, betaxolol, pindolol, propranolol
- Agents with antioxidant effect
Indication differences
- Agents specifically indicated for cardiac arrhythmia
- Esmolol, sotalol, landiolol
- Agents specifically indicated for congestive heart failure
- Bisoprolol, carvedilol, sustained-release metoprolol,
nebivolol
- Agents specifically indicated for glaucoma
- Betaxolol, carteolol, levobunolol, metipranolol, timolol
- Agents specifically indicated for myocardial infarction
- Atenolol, metoprolol, propranolol
- Agents specifically indicated for migraine prophylaxis
Propranolol is the only agent indicated for control of
tremor, portal hypertension and esophageal variceal bleeding, and used
in conjunction with α-blocker therapy in phaeochromocytoma.
Further Reading
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