One of the side effects of Cetuximab therapy is the incidence of, possibly severe, acne-like rash. This rash rarely leads to dose reductions or termination of therapy. It is generally reversible after treatment is finished and may also be associated with a good response to therapy.
As well as severe infusion reactions including but not limited to: fevers, chills, rigors, urticaria, pruritis, rash, hypotension, N/V, HA, bronchospasm, dyspnea, wheezing, angioedema, dizziness, anaphylaxis, and cardiac arrest. Therefore, pretreatment with diphenhydramine 30-60 min. before administration is standard of care.
Other common side effects include photosensitivity, hypomagnesaemia due to magnesium wasting, and less commonly pulmonary and cardiac toxicity.
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