Estradiol Side Effects

By Dr Ananya Mandal, MD

The use of estradiol in medications such as the contraceptive pill or hormone replacement therapy is associated with several adverse effects and some of these are described below:

  • Abnormal vaginal bleeding
  • Painful periods or dysmenorrhea
  • Fibroid enlargement
  • Vaginal infections such as candidiasis
  • Changes in the amount of vaginal secretion
  • Cervical ectropion or cervical erosion/abrasion
  • Galactorrhea or the spontaneous flow of milk from the nipple when a woman is not nursing
  • Nipple discharge

Prolonged use

In cases of prolonged use, the risk of the following side effects is also raised:

  • Ovarian cancer, endometrial cancer, breast cancer
  • Endometrial hyperplasia or thickening of the womb lining
  • Chest pain
  • Deep vein thrombosis
  • Pulmonary embolism
  • Thrombophlebitis
  • Heart attack or myocardial infarction
  • Stroke
  • High blood pressure or hypertension

Skin-related effects

Skin related side effects include skin pigmentation, chloasma and melasma. Other skin effects include loss of scalp hair, erythema multiforme, erythema nodosum, hirsuitism (growth of body hair), itching and rash.

Gastrointestinal effects

When taken orally, the gastrointestinal side effects may include nausea, vomiting, bloating, diarrhea, water retention, jaundice, gall stones, gastritis, dyspepsia, pancreatitis, liver enlargement and liver tumors. Weight gain may also be noted in some women.

Neurological effects

Estradiol medication can cause depression, mood swings, irritability, anger, dizziness and headaches. Epileptic patients may also experience worsening of seizures.

Reviewed by , BSc

Further Reading

Last Updated: Jul 30, 2014

Read in | English | Español | Français | Deutsch | Português | Italiano | 日本語 | 한국어 | 简体中文 | 繁體中文 | Nederlands | Русский | Svenska | Polski
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment