Some medical resources regard ketosis as a physiological state associated with chronic starvation.
Some clinicians regard ketosis as a crisis reaction of the body due to a lack of carbohydrates in the diet and consider it a dangerous and potentially life-threatening state that stresses the liver and causes destruction of muscle tissues.
Ketogenesis does not destroy muscle tissue. Ketogenesis can occur solely from the byproduct of fat degradation: acetyl-CoA.
Ketosis, which is accompanied by gluconeogenesis (the creation of de novo glucose from amino acids), is the specific state with which clinicians are concerned.
The anti-ketosis conclusions have been challenged by a number of doctors and adherents of low-carbohydrate diets, who dispute assertions that the body has a preference for glucose and that there are dangers associated with ketosis.
It has been argued that not only did hunter societies live for thousands of years in a primarily ketogenic state, but also that there are many documented cases of modern humans living in these societies for extended periods of time.
While it is believed by some that exercise requires carbohydrate intake in order to replace depleted glycogen stores, studies have shown that after a period of 2–4 weeks adaptation, physical endurance is unaffected by ketosis[.]
Further Reading
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