Apart from its infamous tendency to induce birth defects and peripheral neuropathy, the main side effects of thalidomide include fatigue and constipation.
It is also associated with an increased risk of deep vein thrombosis especially when combined with dexamethasone, as it is for treatment of multiple myeloma.
High doses can lead to pulmonary oedema, atelectasis, aspiration pneumonia and refractory hypotension.
In multiple myeloma patients, concomitant use with zoledronic acid may lead to increased incidence of renal dysfunction.
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