Toxicology - What is Toxicology?

Toxicology is the study of the adverse effects of chemicals on living organisms. It is the study of symptoms, mechanisms, treatments and detection of poisoning, especially the poisoning of people.

The relationship between dose and its effects on the exposed organism is of high significance in toxicology. The chief criterion regarding the toxicity of a chemical is the dose, i.e. the amount of exposure to the substance.

All substances are toxic under the right conditions. The term LD50 refers to the dose of a toxic substance that kills 50 percent of a test population (typically rats or other surrogates when the test concerns human toxicity).

LD50 estimations in animals are no longer required for regulatory submissions as a part of pre-clinical development package.

The conventional relationship (more exposure equals higher risk) has been challenged in the study of endocrine disruptors.

There are various specialized subdisciplines within the field of toxicology that concern diverse chemical and biological aspects of this area.

For example, toxicogenomics involves applying molecular profiling approaches to the study of toxicology.

Other areas include Aquatic toxicology, Chemical toxicology, Ecotoxicology, Environmental toxicology, Forensic toxicology, and Medical toxicology.

Chemical toxicology is a scientific discipline involving the study of structure and mechanism related to the toxic effects of chemical agents, and encompasses technology advances in research related to chemical aspects of toxicology.

Research in this area is strongly multidisciplinary, spanning computational chemistry and synthetic chemistry, proteomics and metabolomics, drug discovery, drug metabolism and mechanisms of action, bioinformatics, bioanalytical chemistry, chemical biology, and molecular epidemiology.

Further Reading


This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Toxicology" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.

Last Updated: Oct 23, 2013

Read in | English | Español | Français | Deutsch | Português | Italiano | 日本語 | 한국어 | 简体中文 | 繁體中文 | Nederlands | Русский | Svenska | Polski
Comments
  1. Brianna Vick Brianna Vick United States says:

    You mentioned that the LD50 estimations in animals aren't required pre-clinically as they used to be.  I'm curious where you found this information and how recent that change in regulation is?  I would like to know more about this.

  2. Matt Harnden Matt Harnden United States says:

    My name is matthew lee harnden 12/27/90 and I have a strong believe that my mother Sheri Lee ECHE is illegal useing this site on me to collect money and I would like to know please I'm sufferings in some serious pain and I was reading about this and it sounds a lot like she is doing I have been catching on to her and I want her to go to jail for putting me through all theses tests and I need serious help caues she is useing her husband insurance 1 choice Puget sound electrical works under Ben jr ECHE and would  I have all ways wounded  wut all these pains I'm going through and started to catch on please help there address is 15322 b st e Tacoma wa 98445 my number is 253-882-7009 I never gave permission for any of this she has my birth terrific and social security and is identity theft me please help

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post