Vaccine Effectiveness

By Dr Ananya Mandal, MD

Vaccines help the body remember a microorganism to be able to fight it off when the need comes. However, vaccines are not fool proof and do not guarantee complete protection from a disease.

This could be due to various reasons. Sometimes this is because the host's immune system simply doesn't respond adequately or at all. This could be in diseased persons with lowered immunity e.g. in diabetics, those on steroids or other immunity suppressing drugs or those with HIV infection.

The reason for non-development of immunity to a disease could also be because the host's immune system does not have a B cell capable of generating antibodies against the antigen or microbe or the immune system may not be strong enough to fight off the infection.

Efficacy of a vaccine

The efficacy of a vaccine is different from its effectiveness. It is dependent on several factors such as:

  • adherence to vaccine schedules
  • the disease – some diseases have vaccines against them that perform better than for other diseases
  • the strain of vaccine – some vaccine strains are more effective than others
  • non-responders – some individuals do not respond to certain vaccines at all. The cause may lie in the race, ethnicity or genetics of the individual

The mathematical deduction of protective vaccine efficacy is nearly 100 years old, having been proposed by Greenwood and Yule in 1915 for inactivated whole cell cholera and typhoid vaccines.

Measuring vaccine efficacy

Vaccine efficacy is best measured by double-blind, clinical trials. These explore the “best case scenarios” of vaccine protectiveness under controlled conditions and are commonly required before a new vaccine is licensed by the Food and Drug Administration and other global regulatory authorities.

The outcome of efficacy is measured by parameters like - proportionate reduction in disease attack rate (AR) between the unvaccinated (ARU) and vaccinated (ARV) individuals in the clinical trial. This can give the relative risk of getting the disease (RR) of the disease after use of the vaccine.

Efficacy = (ARU-ARV)/ARU X 100

OR

Efficacy = (1-RR) X 100

Advantages and disadvantages of vaccine efficacy

While advantages of knowing the vaccine efficacy means it has been tried in strict clinical conditions, the disadvantages that it has not been tried on larger general populations. Vaccine efficacy studies can measure outcomes beyond disease attack rates, including hospitalizations, medical visits, and costs.

Vaccine effectiveness and “field efficacy”

Vaccine effectiveness was initially termed “field efficacy”. Essentially, vaccine effectiveness is a “real world” view of how a vaccine reduces disease in a population. This vaccine may already have been proved to be efficacious in clinical trials. This measure can assess the net balance of benefits and adverse effects of a vaccination program rather than the vaccine alone in field conditions.

Vaccine effectiveness

Vaccine effectiveness is proportional to vaccine potency or vaccine efficacy but is primarily affected by how well target groups in the population are immunized, difficulties in storing, administering, cost, accessibility, availability, stability and manufacturing of the vaccine.

Effectiveness is expressed as a rate difference. It uses odds ratio (OR) for developing infection despite vaccination and can be derived as:

Effectiveness = (1-OR) X 100.

Considerations for effectiveness of a vaccine

  • effect of the disease on the local prevalence and incidence of the disease it is targeted against. This needs to be considered over medium and long term as well
  • continued surveillance for the relevant disease following introduction of a new vaccine
  • maintenance of high immunization rates, even when a disease has become rare
  • maintenance of availability, adequate stability, low cost and wide coverage of the vaccine

Reviewed by , BA Hons (Cantab)

Further Reading

Last Updated: Oct 14, 2012

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