What are Hepatocellular Carcinomas?

Hepatocellular carcinoma (HCC, also called malignant hepatoma) is a primary malignancy (cancer) of the liver. Most cases of HCC are secondary to either a viral hepatitide infection (hepatitis B or C) or cirrhosis (alcoholism being the most common cause of hepatic cirrhosis).

In countries where hepatitis is not endemic, most malignant cancers in the liver are not primary HCC but metastasis (spread) of cancer from elsewhere in the body, e.g., the colon.

Treatment options of HCC and prognosis are dependent on many factors but especially on tumor size and staging. Tumor grade is also important. High-grade tumors will have a poor prognosis, while low-grade tumors may go unnoticed for many years, as is the case in many other organs, such as the breast, where a ductal carcinoma in situ (or a lobular carcinoma in situ) may be present without any clinical signs and without correlate on routine imaging tests, although in some occasions it may be detected on more specialized imaging studies like MR mammography.

The usual outcome is poor, because only 10 - 20% of hepatocellular carcinomas can be removed completely using surgery. If the cancer cannot be completely removed, the disease is usually deadly within 3 to 6 months. This is partially due to late presentation with large tumours, but also the lack of medical expertise and facilities.

This is a rare tumor in the United States. A new receptor tyrosine kinase inhibitor, sorafenib has been shown in a Spanish phase III clinical trial to add two months to the lifespan of late stage HCC patients with well preserved liver function.

The main risk factors for hepatocellular carcinoma are;

  • alcoholism
  • hepatitis B
  • hepatitis C
  • aflatoxin consumption
  • cirrhosis of the liver
  • Wilsons disease

Hepatocellular Carcinoma may present with jaundice, bloating from ascites, easy bruising from blood clotting abnormalies.

Further Reading


This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Hepatocellular carcinoma" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.

Last Updated: Nov 13, 2013

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Comments
  1. Mawata Miner Mawata Miner United States says:

    My son was diagnosed with Hepatocellular-Carcinoma ( Liver cancer) when he was 15 and he has almost made his way to the 5 year mark, I worry about him everyday and hope he is in the clear! Please give me some inspiration! can he get another cancer? I don't know what to think or maybe I just worry to much!

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