Epidemiological studies show that the incidence of cardiovascular disease (CVD) complications are increased in long standing cases of asthma. Historically, the complications are often attributed to the chronic drug therapy used to treat asthma.
However, researchers in the Department of Physiology, Brody School of Medicine at East Carolina University discovered that the inflammation associated with asthma directly affects the heart’s recovery from a heart attack, confirming the growing body of evidence that indicates asthma may directly, and negatively, impact the cardiovascular system.
“The findings are clinically important because they provide the first evidence of a direct contribution of asthmatic conditions to cardiovascular complications, independent of any asthma drug therapy,” according to Surovi Hazarika, the lead author. “If the findings are confirmed in human trials, asthma could be identified as a potential risk factor for post-operative complications and recurrent events following such cardiology interventions as angioplasty,” she added.
Research for both papers was done by Surovi Hazarika, Michael R. Van Scott and Robert M. Lust of the Department of Physiology, Brody School of Medicine at East Carolina University, Greenville, North Carolina. The studies are part of a collaborative project between the laboratory of Robert M Lust, which studies acute coronary syndromes, and the laboratory of Michael R Van Scott, which studies asthma in animal models.
Improved short- and long-term clinical strategies seen for asthma-CVD co-risks
In the short term this should lead to “improved management strategy of acute coronary syndrome patients with clinical history of asthma. And in the longer term, identification of the precise cause of cardiac changes induced by asthma and the appropriate therapeutic targets should provide better, specific alternatives for patients symptomatic for both asthma and cardiovascular disease, or CVD,” Hazarika predicted.
Study shows asthma “helps” heart attract damaging inflammatory cells
The results of the studies indicate that “inflammatory responses associated with asthma enhance the ability of the heart to attract inflammatory cells when injured, and that the inflammatory cells that are attracted are more prone to be damaging,” Hazarika said. “The end result is increased recruitment of more highly activated neutrophils to the infarct zone during an acute MI, leading to significantly more cardiac tissue damage,” she added.
Evidence for a role of inflammation in the development and progression of cardiovascular diseases has been growing rapidly. Studies demonstrate that blood levels of non-specific biomarkers of systemic inflammation such as C-reactive protein (CRP) correlate with increased risk of myocardial events.
Furthermore, in patients with acute coronary syndrome (ACS), serum myeloperoxidase (MPO) levels, another inflammatory biomarker, indicate the risk of subsequent cardiovascular events. Circulating white blood cells, called neutrophils, are an important part of the immune system, and are the predominant source of MPO. Neutrophils have been shown to play a key role in myocardial infarction (MI, or heart attack), as well as in recovery from MI.
Finding the asthma mechanisms that increase cardiac injury