A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells, report researchers from Georgetown University Medical Center and the Institute for Cancer Prevention.
They say the results, published in a set of papers in the current issue of Cancer Research, suggest that these chemicals - put into a veggie pill of sorts - might some day be used to help current and former smokers ward off development of lung cancer, the leading cause of cancer death in Americans.
"These studies provides significant insight into the mechanisms of lung cancer prevention and suggests ways the process can be slowed down after exposure has already occurred," said the study's principal investigator Fung-Lung Chung, Ph.D., Professor of Oncology in the Lombardi Cancer Center at the Georgetown University Medical Center. He worked with researchers from the Institute for Cancer Prevention, in Valhalla, New York, and with other scientists in Illinois, Minnesota and New York on the studies.
"We still need to do more research, but it may be that an agent containing these ingredients could, to some degree, help protect people who have developed early lung lesions due to smoking," Chung said. "In any case, we know that eating vegetables is generally good for us, and that some studies have shown they help lower a person's risk of developing cancer."
One of the two new studies being reported was the first to test whether these compounds, derived from naturally occurring isothiocyanates, could have an impact on the stages of cancer development specifically after exposure to cancer-causing elements . To test that, the researchers induced lung tumor development in experimental mice by exposing them to tobacco carcinogens, and then they fed one group of mice the veggie compounds. They found that, indeed, use of the chemicals resulted in a reduced development of benign (harmless) lung tumors to malignant tumors, compared to mice that did not receive the compound.