About one in a hundred patients with apparently incurable non-small cell lung cancer (NSCLC) survive five or more years after being given relatively small doses of radiation therapy (RT) meant to ease symptoms, according to a new study.
Published in the March 1, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study says a new subset of patients with NSCLC appears to have disease that is curable with minimal therapy, and may explain occasional cures attributed to unconventional therapies or faith healing.
NSCLC is by far the most common type of lung cancer. With an overall five year survival of only 40 percent, it is also one of the deadliest. If caught early, five year survival can reach 60 percent. Five year survival in farther advanced disease is approximately 15 percent.
Patients who are diagnosed with disease that is too advanced for curative treatment remain eligible for palliative therapies intended to provide symptom relief, including comparatively low doses of localized RT. Physicians have long made clinical observations that some patients receiving palliative RT long outlive their estimated survival and a few report even cures. Given that therapeutic doses of RT are much higher, it is not surprising that these reports require evidence-based confirmation.
Michael Mac Manus, M.D., a radiation oncologist at the Peter MacCallum Cancer Centre in Melbourne, Australia, and colleagues clinically followed 2337 confirmed and apparently incurable NSCLC patients who had received palliative dose RT.