People with type 2 diabetes have highly acidic urine, a metabolic feature that explains their greater risk for developing uric-acid kidney stones, researchers at UT Southwestern Medical Center have found.
The study - the first to compare the urinary biochemical characteristics of type 2 diabetics with those of normal volunteers - is available online and will be published in the May issue of the Journal of the American Society of Nephrology.
Individuals with type 2 diabetes (non-insulin dependent diabetes mellitus) are at increased risk for developing kidney stones in general, and have a particular risk for uric-acid stones. The mechanisms for this greater risk were previously not entirely understood. This new study demonstrates that the propensity for type 2 diabetics to develop uric-acid stones is elevated because their urine is highly acidic.
"Our next step is to find out what causes type 2 diabetics to have an abnormally acidic urine, and what other urinary factors protect some diabetics who do not form uric-acid stones," said Dr. Mary Ann Cameron, the paper's lead author and a postdoctoral trainee in internal medicine.
Obesity and a diet rich in animal protein are associated with abnormally acidic urine. In earlier studies, UT Southwestern researchers also concluded that uric-acid stones are associated with insulin resistance and type 2 diabetes.
But when researchers in this latest study accounted for these components, type 2 diabetics continued to have more acidic urine levels when compared to nondiabetics. These findings suggest that other factors associated with type 2 diabetes or insulin resistance account for the overly acidic urine in this population.
"Diet intake and obesity, those two factors alone, don't explain the whole picture," said Dr. Naim Maalouf, an author and assistant professor of internal medicine. "So, other unrecognized factors may play a role."