A combination of two medicines that act against the effects of the enzyme renin are more effective in lowering blood pressure than either of the medicines alone, according to a study presented today at the American College of Cardiology's 56th Annual Scientific Session.
Aliskiren and valsartan have both been shown to have anti-hypertensive effects when given individually, but this is the first study that pairs the two in patients with mild to moderate high blood pressure. ACC.07 is the premier cardiovascular medical meeting, bringing together cardiologists and cardiovascular specialists to further breakthroughs in cardiovascular medicine.
Renin is an enzyme produced in the kidneys that initiates a cascade of events that generates angiotensin, a hormone which constricts the arteries, raising blood pressure as a result. Aliskiren is the first in a class of orally administered direct renin inhibitors, while valsartan is an angiotensin receptor blocker that impedes the effects of angiotensin by relaxing the blood vessels.
In a double-blind, placebo-controlled study, 1,797 patients were randomized to one of four treatment arms: the combination of 150 mg of aliskiren and 160 mg of valsartan, 150 mg of just aliskiren, 160 mg of just valsartan, or simply placebo once daily for four weeks. Then, the doses were doubled for a second four weeks. Blood pressure was checked at baseline and again and four and at eight weeks.
2 :2 : 2 Renin Blocker Therapy