Allergies, like the common cold and asthma, have basically defied the best efforts of modern medicine to cure them.
Now, a doctoral candidate at the Hebrew University of Jerusalem School of Pharmacy has come up with a new approach that offers hope for getting rid of them.
For his efforts, Chilean-born Ido Bachelet, a first cousin of the president of Chile, Michelle Bachelet, and a Ph.D. student under the supervision of Prof. Francesca Levi-Schaffer, has been named the winner of one of this year's Barenholz Prizes for Creativity and Originality in Applied Research. The award, named for its donor, Yehezkel Barenholz, the Dr. Daniel G. Miller Professor of Cancer Research at the Hebrew University-Hadassah Medical School, was presented recently during the Hebrew University Board of Governors 70th meeting.
Bachelet's research has focused on mechanisms that regulate the function of mast cells the villains in triggering allergic reactions. When exposed to allergens, mast cells react violently and release an enormous array of pro-inflammatory substances, of which histamine is a well known example. These substances lead to acute symptoms ranging from stuffy nose, rash, and airway constriction to the lethal shock known from food or venom allergies. Later on, they attract inflammatory cells that will maintain the response, which often persists as a chronic disease.
Although allergies are usually not perceived as lethal, reality is different. In 2005, over 250,000 people died from asthma worldwide. The World Health Organization estimates that this rate will increase by 20 percent within the next decade if urgent action is not taken. Asthma is the most common chronic disease among children.
Bachelet has identified a receptor protein on mast cells, termed CD300a. This receptor has a prominent negative effect on mast cell activity, virtually shutting down the cell from unleashing allergic responses. Unfortunately, CD300a is widely found throughout the immune system, and simply targeting it could result in undesired, overall immune suppression with serious consequences, as can happen with steroids.