Tumors require a blood supply to grow, but how they acquire their network of blood vessels is poorly understood.
A new study here shows that tumor blood vessels can develop from precancerous stem cells, a recently discovered type of cell that can either remain benign or become malignant.
Researchers say the findings provide new information about how tumors develop blood vessels, and why new drugs designed to block tumor blood-vessel growth are often less effective than expected.
The study by scientists at the Ohio State University Comprehensive Cancer Center and Department of Pathology is to be published Feb. 20 in the journal PLoS ONE.
“These findings suggest that tumor blood vessels are derived mainly from tumor cells, with a smaller number coming from normal blood-vessel cells,” says principal investigator Jian-Xin Gao, assistant professor of pathology.
“This may explain why many anti-angiogenic drugs fail to block tumor growth.”
Gao notes that potential anti-angiogenic drugs are usually screened using normal blood-vessel cells, also called endothelial cells, or their progenitors.
“The screened drugs may be very good at blocking the formation of blood vessels made by normal endothelial cells, but have little effect on blood-vessel formation by precancerous stem cells or other blood-vessel-forming cancer cells,” Gao says. “Our findings suggest that screening of these agents should include precancerous stem cells.”
Normal stem cells are unspecialized cells that can give rise to other types of cells. Recent evidence suggests that tumors consist of a small number of cancerous stem cells, or cancer-propagating cells with some features of stem cells, and a large number of their malignant progeny.
Precancerous stem cells are thought to be cells that can remain noncancerous or progress to cancer, depending on subsequent environmental influences.