A team of researchers from the University of the Basque Country (UPV-EHU) have developed a mathematical classification which makes it possible to select human embryos for use in assisted reproduction treatments. Scientists have used the morphology of embryos to select the best candidates for implantation in the woman's uterus.
"Up to now experts working in in vitro fertilisation have selected the best embryos subjectively, based on their training and experience", so SINC was informed by Dinora A. Morales, from the Intelligent Systems Group at the UPV-EHU. However, in two studies carried out by researchers from this team the use of mathematical classifiers to help embryologists with that task was looked at.
In the first work, published in the journal Computer Methods and Programs in Biomedicine, the scientists presented an "intelligent system" of support for infertility treatments. For this they used information from 63 cases from the infertility programme at Clínica del Pilar in San Sebastian (Guipúzcoa), and analysed the evolution of trios of embryos (Spanish law allows for the transfer of up to three embryos to a woman's uterus).
To prepare the study, the researchers focused on the case history of infertile couples (age, type of infertility, quality of sperm, etc), as well as the morphological characteristics of the zygote (the resulting cell from the fusion of two gametes) and the embryos.
From the images taken with the microscope, the scientists were able to measure and classify the zygotes and embryos, as well as the blastomeres (undifferentiated animal cells produced by the division of the zygote), their degree of fragmentation and the thickness of the 'zona pellucida', a membrane that surrounds them.