Larval (maggot) therapy has similar health benefits and costs compared with a standard treatment for leg ulcers, find two studies published on bmj.com.
Leg ulcers are chronic wounds most commonly caused by diseased veins in the legs. Debridement (the removal of dead tissue from the ulcer surface) is a common part of ulcer management and is widely viewed as having a role in promoting wound healing.
Debridement can be undertaken with a hydrogel, but it has been suggested that larval therapy debrides wounds more swiftly, as well as stimulating healing and reducing infection.
A team of UK researchers have carried out the first randomised controlled trial to investigate the clinical and cost-effectiveness of larval therapy on wound healing.
The trial involved 267 participants who had at least one venous or mixed venous/arterial leg ulcer with dead tissue (sloughy and/or necrotic tissue) covering at least a quarter of the wound.
Participants were randomised to receive loose larvae, bagged larvae or hydrogel during the debridement phase, followed by standard treatment. People were monitored for up to 12 months, during which time the date of complete healing of the ulcer was recorded by trained nurses.
Date of debridement was also recorded, as were bacterial levels, adverse events and ulcer-related pain. Participants completed a health-related quality of life questionnaire at the start of the study, and then again at three, six, nine and 12 months.
Larval therapy significantly reduced the time to debridement compared with hydrogel, but there was no evidence of a difference in time to ulcer healing (half of patients allocated to the larvae group were healed by 236 days compared with 245 days for the hydrogel group).