PolyMedix, Inc. (OTC BB: PYMX, http://polymedix.com), an emerging biotechnology company developing new therapeutic drug products to treat infectious diseases and acute cardiovascular disorders based on biomimetics, has received patent protection for certain exclusively licensed intellectual property by the issuance to the University of Pennsylvania of U.S. patent number 7,590,517, “Methods, Systems, and Computer Program Products for Computational Design of Amphiphilic Polymers.”
This patent claims the underlying process and implementation of two proprietary computational methodologies: PACE™ (Proteomic Assisted Computational Engine) and GOLDYN™ (Global Optimization of Long-time Dynamics force field), useful for the de novo design of small molecule mimetics. It relates to the identification of stable conformations of polymers and polymer fragments (oligomers) by computing force fields for the target compounds, and then predicting their conformations using molecular dynamics and configurational-biased simulations. This methodology enables the design of small amphiphilic polymers or oligomers, taking into account backbone structures, side-chain architectures and solvent effects, and improves the likelihood of synthesizing compounds with desired properties.