NTI awards $295,172 to BMC chief for acute lung injury study

Suresh Agarwal, MD, the chief of surgical critical care at Boston Medical Center (BMC) and an associate professor of medicine at Boston University School of Medicine (BUSM), has received a $295,172 grant from the National Trauma Institute (NTI) to identify optimal treatment methods for acute lung injury (ALI). BMC will lead the multi-institutional trial, which involves seven level one trauma centers and includes one military hospital.

Agarwal's study is one of nine grants awarded this year by NTI, a non-profit organization dedicated to funding trauma research in the United States in an effort to reduce death and disability, and the associated costs, related to trauma injury.

Agarwal will study two therapies that may influence ALI, a significant healthcare burden for both military and civilian populations that accounts for more than 75,000 deaths annually. Mechanical ventilation (respirator) techniques remain the only accepted treatment therapy for patients with severe injuries, but these are also associated with segmental lung collapse, increased time on a ventilator and increased incidence of pneumonia. Agarwal's team will compare a novel therapy, airway pressure release ventilation (APRV), with ARDSNet (Acute Respiratory Distress Syndrome), the traditional modality for management of ALI.

"Our long-term goal is to improve the health outcomes of patients with ALI and ARDS and gain a better understanding of its pathogenesis, prevention and treatment," said Agarwal.