Risk of gout flare-ups greatly increased by purine rich foods

Published on May 31, 2012 at 5:49 AM · No Comments

Foods rich in purines, particularly those found in meat and seafood, quintuple the immediate risk of a gout flare-up, finds research published online in the Annals of the Rheumatic Diseases.

While the anecdotal evidence has suggested that purine rich foods can trigger gout attacks, it hasn’t been clear whether they prompt flare-ups in the short term, say the authors.

They base their findings on 633 people with confirmed gout, whose health was tracked over a year, online. The average age of the participants was 54, and most of them (78%) were men.

They were asked to provide details of history of gout attacks, including the timing and symptoms of the attack; what drugs they were taking to manage their condition; and to list any potential triggers in the two days running up to an attack.

This included dietary sources of purines. Foods rich in purines include meat, offal, seafood, beans, peas, lentils, oatmeal, spinach, asparagus, mushrooms, yeast, and alcohol.

They were also asked to provide the same information over two-day periods every quarter when they were not experiencing a flare-up, by way of a comparison.

Over half drank alcohol (61%), a known risk factor for the condition, while 29% used water pills (diuretics) and almost half took allopurinol—a drug used to prevent gout attacks.

Over half used non-steroidal anti-inflammatory drugs, while one in four (25%) took colchicines, another class of anti-gout drug.

During the 12 month monitoring period, 1,247 gout attacks were recorded, most of which occurred in the toe joints, causing intense pain and redness.

The average amount of dietary purine during a two-day period without gout attacks was 1.66 g, while that consumed in the two days before an attack was 2.03 g.

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