Seth Lederman, M.D., President and CEO of New York City-based Tonix Pharmaceuticals Holding Corp. (OTCBB:TNXP) says that a good night’s sleep is a potentially powerful, but currently elusive, treatment for the chronic pain and sleep disorders suffered by patients with fibromyalgia (FM), post-traumatic stress disorder (PTSD), traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE).
He also said that a promising new drug under development by TONIX for treating FM, whose symptoms include pain and sleeping problems, might be able to provide the restful sleep that would help people with these conditions.
Dr. Lederman points out that chronic pain and sleep disorders are common problems in FM, PTSD, TBI and CTE. Many patients have learned that their symptoms can be eased after a restful night’s sleep. However, part of the decompensation that’s common in all these conditions happens when the pain syndrome makes it impossible to get restful sleep.
It is suspected that TBI or CTE may have been factors in the suicide deaths of several National Football League players, including Junior Seau. Numerous suicides among soldiers returning from combat in Afghanistan and Iraq have been linked to PTSD or TBI. Many patients who suffer from either TBI or CTE wind up abusing sleep and pain medicines.
“Many people with FM, PTSD and TBI desperately try to dampen their pain and to get sleep by taking opiate painkillers and prescription sleep drugs”, says Dr. Lederman, “but those drugs don’t really help,” says Dr. Lederman. “The reason is that the patients’ pain comes from their brains, not their bodies,” he explained.
“Scientists believe that the brain uses the same areas to experience pain as it uses to re-experience painful memories. That potentially explains why the traumatic memories of PTSD patients feel like real pain. And in FM, those same pain centers may also be activated. That would explain why FM patients also experience chronic pain—and why normal painkillers don’t work for them either,” Dr. Lederman noted.