Expression of soluble CD40L has been shown to increase sig-nificantly in conditions such as stroke, myocardial infarction, unstable angina, high cholesterol, or other cardiovascular events. 95% of the circulating CD40L exists in activated platelets. However, the specific pathway of the transition of CD40L is not elucidated, and whether Golgi apparatus is involved in the expression of platelet CD40L still needs to be proven.
Dr. Wei Lu and colleagues from Second Xiangya Hospital, Central South University, found that platelet Golgi apparatus displayed significant morphological changes, which were possibly associated with enhanced synthetic and secretory functions of activated platelets after acute cerebral infarction. Golgi apparatus participated in the synthesis and transport of CD40L to the platelet surface, which may be a new target for the treatment of acute cerebral infarction. These findings were published in the Neural Regeneration Research (Vol. 8, No. 23, 2013).
Novel cholesterol removal strategy shows potential benefits post-heart attack