Incyte enters into clinical trial collaboration agreement with Merck to evaluate safety of IDO1 inhibitor

Published on February 5, 2014 at 7:50 AM · No Comments

Incyte Corporation (Nasdaq: INCY) announced today that it has entered into a clinical trial collaboration agreement with Merck, through a Merck subsidiary, to evaluate the safety and efficacy of Incyte's oral indoleamine dioxygenase-1 (IDO1) inhibitor, INCB24360, and Merck's investigational anti-PD-1 immunotherapy, MK-3475, in a Phase I/II study in previously treated metastatic and recurrent non-small cell lung cancer (NSCLC), and other advanced or metastatic cancers.

Both INCB24360 and MK-3475 are part of a new class of cancer treatments known as immunotherapies that are designed to enhance the body's own defenses in fighting cancer. INCB24360 and MK-3475 target distinct regulatory components of the immune system, and there is preclinical evidence suggesting that the combination of these two agents may lead to an enhanced anti-tumor immune response than either agent alone.

"The field of immunotherapy is evolving rapidly. Given the synergistic activity we have seen with our IDO1 inhibitor when combined with checkpoint inhibitors in preclinical models, we look forward to working with Merck on this initial clinical collaboration," stated Hervé Hoppenot, President and Chief Executive Officer of Incyte. "To further our understanding of the therapeutic value of our IDO1 inhibitor, we intend to establish additional clinical collaborations with other companies, cancer networks and academia."

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