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The adrenal glands are the part of the body responsible for releasing three different classes of hormones. These hormones cont, controlling the "fight or flight" response to stress, maintaining pregnancy, initiating and controlling sexual maturation during childhood and puberty. The adrenal glands are also an important source of sex steroids, such as estrogen and testosterone.
Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'. [More]
New MRI contrast agent detects tiny breast cancer tumors, micrometastases

New MRI contrast agent detects tiny breast cancer tumors, micrometastases

Researchers at Case Western Reserve University have developed a magnetic resonance imaging (MRI) contrast agent that detects much smaller aggressive breast cancer tumors and micrometastases than current agents can identify. [More]
New research could help develop precision medicine for primary aldosteronism

New research could help develop precision medicine for primary aldosteronism

Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high. [More]
New approach may offer improved way to detect early breast cancer

New approach may offer improved way to detect early breast cancer

Researchers have shown that magnetic resonance imaging (MRI) can detect the earliest signs of breast cancer recurrence and fast-growing tumors. Their approach detects micromestastases, breakaway tumor cells with the potential to develop into dangerous secondary breast cancer tumors elsewhere in the body. [More]
Endocrine Society recommends removal of tumor as first-line treatment for endogenous Cushing's syndrome

Endocrine Society recommends removal of tumor as first-line treatment for endogenous Cushing's syndrome

The Endocrine Society today issued a Clinical Practice Guideline (CPG) on strategies for treating Cushing's syndrome, a condition caused by overexposure to the hormone cortisol. [More]
Blunted cortisol response common in non-classic CAH

Blunted cortisol response common in non-classic CAH

Nearly two-thirds of children with non-classic congenital adrenal hyperplasia have an inadequate cortisol response, report researchers. [More]
Researchers develop artificial adrenal system in animal model

Researchers develop artificial adrenal system in animal model

If the function of the adrenal gland is disturbed it does not produce enough stress-adjusting messengers. The results are serious and cause life-threatening diseases. Under the direction of Prof. Dr. Stefan R. Bornstein of the university hospital Carl Gustav Carus researchers developed an artificial adrenal system together with the medicine Nobel Prize Laureate Prof. Dr. Andrew Schally in an animal model. [More]
Not all ARB drugs are equally effective at treating heart failure, reveals NSU researcher

Not all ARB drugs are equally effective at treating heart failure, reveals NSU researcher

Millions of people take angiotensin receptor blockers (ARBs) to help treat heart failure. But it turns out not all ARBs are created equally, according to one Nova Southeastern University researcher's findings. [More]
Study: Mutated ATRX gene may serve as much-needed biomarker for rare neuroendocrine tumors

Study: Mutated ATRX gene may serve as much-needed biomarker for rare neuroendocrine tumors

A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors. Now, for the first time, researchers at Penn's Abramson Cancer Center have found that the same mutated gene may serve as a much-needed biomarker for the pheochromocytomas and paragangliomas (PCC/PGL) that become malignant. [More]
Patients with Cushing’s syndrome experience significant weight loss while taking oral medication

Patients with Cushing’s syndrome experience significant weight loss while taking oral medication

Sinai Hospital of Baltimore endocrinologist, Henry G. Fein, M.D., today presented new research showing that patients with Cushing's syndrome, a rare disease that can lead to extreme weight gain, type 2 diabetes, high blood pressure and psychological issues, experienced significant, sustained weight loss while taking oral medication daily over a number of years to manage symptoms of the disease. [More]
Single dose restores normal cellular signaling in mouse model of autism

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old. [More]
Forest publishes data from pivotal Phase III Study of Investigational FDC of nebivolol and valsartan

Forest publishes data from pivotal Phase III Study of Investigational FDC of nebivolol and valsartan

Forest Laboratories, Inc. (NYSE:FRX) today announced the publication of data from its pivotal Phase III Study of an Investigational Fixed-Dose Combination (FDC) of nebivolol and valsartan in the May 30, 2014 issue of The Lancet. [More]
Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research. [More]
LMU researchers identify genetic mutations that result in overproduction of cortisol

LMU researchers identify genetic mutations that result in overproduction of cortisol

An international team of researchers led by an endocrinologist at Ludwig-Maximilians-Universitaet (LMU) in Munich has identified genetic mutations that result in uncontrolled synthesis and secretion of the stress hormone cortisol. [More]
New study sheds light on the progression and management of ‘silent’ adrenal tumours

New study sheds light on the progression and management of ‘silent’ adrenal tumours

CT scans are increasingly performed for a variety of medical indications, including for general health screening, which is growing in popularity. An estimated 4% of CT scans will coincidentally uncover a tumour in the adrenal gland, with no associated clinical symptoms. However, until now, evidence on how to manage these ‘silent’ tumours has been lacking, despite the fact that the growing demand for CT scans is likely to lead to increasing numbers of detections. [More]
Study reveals why people are predisposed to cardiovascular disease and death

Study reveals why people are predisposed to cardiovascular disease and death

A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists at Duke Medicine report. [More]
Study: Antisense drugs show activity in wide range of tissues and organs

Study: Antisense drugs show activity in wide range of tissues and organs

Antisense therapeutics, a class of drugs comprised of short nucleic acid sequences, can target a dysfunctional gene and silence its activity. A new study has shown that antisense drugs delivered systemically show activity in a wide range of tissues and organs, supporting their broad therapeutic potential in many disease indications, as described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [More]
New data questions surgical options for treating kidney cancer

New data questions surgical options for treating kidney cancer

Surgery is often the first step in treating kidney cancer, and new data from the University of Rochester Medical Center, which contradicts earlier research, questions whether removal of only the tumor (partial nephrectomy) is better than removing the entire kidney (radical nephrectomy). [More]
IDIBELL signs patent licensing agreement with Minoryx

IDIBELL signs patent licensing agreement with Minoryx

The Bellvittge Biomedical Research Institute has signed a licensing agreement with the Spanish biotechnology company Minoryx of a patent for the treatment of X-linked adrenoleukodystrophy, a rare serious neurodegenerative disease which has no effective treatment. [More]
Microwave ablation therapy reduces pain in patients with painful bone, soft-tissue tumors

Microwave ablation therapy reduces pain in patients with painful bone, soft-tissue tumors

First-of-its-kind research presented today showed microwave ablation therapy cut pain in half for patients with painful bone and soft-tissue tumors and took less time to complete than radiofrequency ablation. [More]
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