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The adrenal glands are the part of the body responsible for releasing three different classes of hormones. These hormones cont, controlling the "fight or flight" response to stress, maintaining pregnancy, initiating and controlling sexual maturation during childhood and puberty. The adrenal glands are also an important source of sex steroids, such as estrogen and testosterone.
Patients with Cushing’s syndrome experience significant weight loss while taking oral medication

Patients with Cushing’s syndrome experience significant weight loss while taking oral medication

Sinai Hospital of Baltimore endocrinologist, Henry G. Fein, M.D., today presented new research showing that patients with Cushing's syndrome, a rare disease that can lead to extreme weight gain, type 2 diabetes, high blood pressure and psychological issues, experienced significant, sustained weight loss while taking oral medication daily over a number of years to manage symptoms of the disease. [More]
Single dose restores normal cellular signaling in mouse model of autism

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old. [More]
Forest publishes data from pivotal Phase III Study of Investigational FDC of nebivolol and valsartan

Forest publishes data from pivotal Phase III Study of Investigational FDC of nebivolol and valsartan

Forest Laboratories, Inc. (NYSE:FRX) today announced the publication of data from its pivotal Phase III Study of an Investigational Fixed-Dose Combination (FDC) of nebivolol and valsartan in the May 30, 2014 issue of The Lancet. [More]
Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

Patient with advanced bladder cancer shows complete response to everolimus and pazopanib drugs

A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research. [More]
LMU researchers identify genetic mutations that result in overproduction of cortisol

LMU researchers identify genetic mutations that result in overproduction of cortisol

An international team of researchers led by an endocrinologist at Ludwig-Maximilians-Universitaet (LMU) in Munich has identified genetic mutations that result in uncontrolled synthesis and secretion of the stress hormone cortisol. [More]
New study sheds light on the progression and management of ‘silent’ adrenal tumours

New study sheds light on the progression and management of ‘silent’ adrenal tumours

CT scans are increasingly performed for a variety of medical indications, including for general health screening, which is growing in popularity. An estimated 4% of CT scans will coincidentally uncover a tumour in the adrenal gland, with no associated clinical symptoms. However, until now, evidence on how to manage these ‘silent’ tumours has been lacking, despite the fact that the growing demand for CT scans is likely to lead to increasing numbers of detections. [More]
Study reveals why people are predisposed to cardiovascular disease and death

Study reveals why people are predisposed to cardiovascular disease and death

A genetic trait known to make some people especially sensitive to stress also appears to be responsible for a 38 percent increased risk of heart attack or death in patients with heart disease, scientists at Duke Medicine report. [More]
Study: Antisense drugs show activity in wide range of tissues and organs

Study: Antisense drugs show activity in wide range of tissues and organs

Antisense therapeutics, a class of drugs comprised of short nucleic acid sequences, can target a dysfunctional gene and silence its activity. A new study has shown that antisense drugs delivered systemically show activity in a wide range of tissues and organs, supporting their broad therapeutic potential in many disease indications, as described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [More]
New data questions surgical options for treating kidney cancer

New data questions surgical options for treating kidney cancer

Surgery is often the first step in treating kidney cancer, and new data from the University of Rochester Medical Center, which contradicts earlier research, questions whether removal of only the tumor (partial nephrectomy) is better than removing the entire kidney (radical nephrectomy). [More]
IDIBELL signs patent licensing agreement with Minoryx

IDIBELL signs patent licensing agreement with Minoryx

The Bellvittge Biomedical Research Institute has signed a licensing agreement with the Spanish biotechnology company Minoryx of a patent for the treatment of X-linked adrenoleukodystrophy, a rare serious neurodegenerative disease which has no effective treatment. [More]
Microwave ablation therapy reduces pain in patients with painful bone, soft-tissue tumors

Microwave ablation therapy reduces pain in patients with painful bone, soft-tissue tumors

First-of-its-kind research presented today showed microwave ablation therapy cut pain in half for patients with painful bone and soft-tissue tumors and took less time to complete than radiofrequency ablation. [More]
Mindfulness meditation can reduce stress hormone

Mindfulness meditation can reduce stress hormone

Focusing on the present rather than letting the mind drift may help to lower levels of the stress hormone cortisol, suggests new research from the Shamatha Project at the University of California, Davis. [More]
Algorithm similar to Google PageRank helps map spread of lung cancer

Algorithm similar to Google PageRank helps map spread of lung cancer

The same sort of mathematical model used to predict which websites people are most apt to visit is now showing promise in helping map how lung cancer spreads in the human body, according to a new study published in the journal Cancer Research. [More]
Researchers: Acupuncture can reduce stress hormone response in animal model of chronic stress

Researchers: Acupuncture can reduce stress hormone response in animal model of chronic stress

While acupuncture is used widely to treat chronic stress, the mechanism of action leading to reported health benefits are not understood. In a series of studies at Georgetown University Medical Center, researchers are demonstrating how acupuncture can significantly reduce the stress hormone response in an animal model of chronic stress. [More]
Steroids used for treating TB may reduce death rates from all types of TB

Steroids used for treating TB may reduce death rates from all types of TB

The routine use of steroids to treat tuberculosis may help reduce deaths from all types of the disease, according to a new review of existing research. [More]
PCOS causes double jeopardy for those struggling hard to control glucose levels

PCOS causes double jeopardy for those struggling hard to control glucose levels

Polycystic ovary syndrome, a condition affecting about 10 percent of women and characterized by excess male hormone and increased risk of diabetes and heart disease, appears to cause a sort of double jeopardy for those struggling the hardest to control blood sugar levels, researchers report. [More]
Newborn screening improves detection of lethal form of congenital adrenal hyperplasia (CAH) in girls as well as boys

Newborn screening improves detection of lethal form of congenital adrenal hyperplasia (CAH) in girls as well as boys

Contrary to current belief, routine newborn screening improves the detection of the lethal form of congenital adrenal hyperplasia (CAH) in girls as well as boys, saving lives in both sexes, according to a unique study of CAH during the last 100 years published Online First in The Lancet Diabetes and Endocrinology. [More]
Early detection, treatment needed to reduce risk of death and CVD in older Cushing's disease patients

Early detection, treatment needed to reduce risk of death and CVD in older Cushing's disease patients

Even after successful treatment, patients with Cushing's disease who were older when diagnosed or had prolonged exposure to excess cortisol face a greater risk of dying or developing cardiovascular disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). [More]
Investigators use genome analysis to eliminate lifetime drug prescription in two children

Investigators use genome analysis to eliminate lifetime drug prescription in two children

Using genome-wide analysis, investigators at the Sainte-Justine University Hospital Research Center and the University of Montreal have potentially eliminated a lifetime drug prescription that two children with a previously unknown type of adrenal insufficiency had been receiving for 14 years. [More]
Heart transplant patient becomes unexpected ambassador for organ donation

Heart transplant patient becomes unexpected ambassador for organ donation

Kevin Riepl arrived at Cedars-Sinai in October 2010, suffering from sudden heart failure that left him fighting for his life. Surgeons swiftly installed a heart pump and later transplanted a new heart, saving his life and turning him into an unexpected ambassador for organ donation. [More]