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Breast cancer is cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare. When breast cancer cells spread to other parts of the body, they are called metastases. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer. Breast cancer can begin in different parts of the breast, like the ducts or the lobes.
Two orphan receptor proteins exert fatal double whammy effect against glioblastoma cells

Two orphan receptor proteins exert fatal double whammy effect against glioblastoma cells

Two related proteins exert a lethal double whammy effect against glioblastoma cells when activated with a small molecule, say researchers at Georgetown Lombardi Comprehensive Cancer Center. [More]
Survey highlights need for increased public education on benefits of lung cancer screening in France

Survey highlights need for increased public education on benefits of lung cancer screening in France

A prospective nationwide survey on perceptions of lung cancer in the general population of France highlights a need for increased public education on the benefits of lung cancer screening, the good survival rates of early-stage disease and the improved outcomes with new therapeutic strategies, including targeted-therapies. [More]
New study identifies how SNAIL gene helps cancer cells break free from primary tumor

New study identifies how SNAIL gene helps cancer cells break free from primary tumor

More than 90 percent of cancer-related deaths are caused by the spread of cancer cells from their primary tumor site to other areas of the body. A new study has identified how one important gene helps cancer cells break free from the primary tumor. [More]
Researchers find new 'sliding scale' model to rule out blood clots in lungs

Researchers find new 'sliding scale' model to rule out blood clots in lungs

Researchers from Intermountain Medical Center in Salt Lake City have identified a new "sliding scale" model used to rule out potentially deadly blood clots in the lungs, known as pulmonary embolisms, that is more accurate than current diagnostic methods. [More]
Investigational drug increases PFS in patients with advanced breast cancer

Investigational drug increases PFS in patients with advanced breast cancer

In a groundbreaking study that offers new hope for women with advanced breast cancer, researchers from UCLA's Jonsson Comprehensive Cancer Center have published final clinical trial results that showed the amount of time patients were on treatment without their cancer worsening (called progression-free survival) was effectively doubled in women with advanced breast cancer who took the experimental drug palbociclib. [More]
UVA study finds that measurement of breast density better predicts woman's breast cancer risk

UVA study finds that measurement of breast density better predicts woman's breast cancer risk

A new study from UVA Cancer Center found that adding a measurement of breast density better predicts women's risk for breast cancer. Including breast density as part of risk models for breast cancer could support the development of a personalized risk model to recommend how often a woman should have a mammogram based on her unique risk factors. [More]
UTSA receives NIH grant to develop bioinformatics tools to find cause of breast cancer

UTSA receives NIH grant to develop bioinformatics tools to find cause of breast cancer

According to the American Cancer Society, breast cancer is the most common cancer among American women, except for skin cancers, and about one in eight women in the United States will develop invasive breast cancer during their lifetime. The National Institutes of Health recently awarded a $1.08 million grant to The University of Texas at San Antonio to combine computational modeling with biological information to advance our understanding of what may cause breast cells to become cancerous. [More]
UT Southwestern researchers identify cell signaling mechanism that plays vital role in brain cancer

UT Southwestern researchers identify cell signaling mechanism that plays vital role in brain cancer

UT Southwestern Medical Center neurology researchers have identified an important cell signaling mechanism that plays an important role in brain cancer and may provide a new therapeutic target. [More]
UC Davis researchers uncover complex relationship between p53 and Rbm38 proteins

UC Davis researchers uncover complex relationship between p53 and Rbm38 proteins

Scientists have long known the p53 protein suppresses tumors. However, a recent animal study by UC Davis researchers has uncovered a complicated relationship between p53 and another protein, Rbm38, highlighting how the body calibrates protein levels. Too much Rbm38 reduces p53 levels, increasing the risk of cancer. [More]
New MIT study implicates RNA-binding proteins in regulation of cancer

New MIT study implicates RNA-binding proteins in regulation of cancer

A new study from MIT implicates a family of RNA-binding proteins in the regulation of cancer, particularly in a subtype of breast cancer. These proteins, known as Musashi proteins, can force cells into a state associated with increased proliferation. [More]
Trastuzumab drug improves long-term survival of patients with HER-2 positive breast cancer

Trastuzumab drug improves long-term survival of patients with HER-2 positive breast cancer

VCU Massey Cancer Center physician-researcher Charles E. Geyer, Jr., M.D., was the National Protocol Officer for one component of a large national study involving two National Cancer Institute-supported clinical trials that demonstrated that trastuzumab significantly improves the long-term survival of HER-2 positive breast cancer patients. [More]
Two-drug combination before surgery benefits women with triple-negative breast cancer

Two-drug combination before surgery benefits women with triple-negative breast cancer

A breast cancer specialist and clinical researcher at Women & Infants Hospital of Rhode Island presented research yesterday at the 2014 San Antonio Breast Cancer Symposium showing that adding either the chemotherapy drug carboplatin or the blood vessel-targeting drug bevacizumab to the standard treatment of chemotherapy before surgery helped women who have the basal-like subtype of triple-negative breast cancer. [More]
Revolutionising back pain treatments: an interview with Dr Kieran O’Sullivan

Revolutionising back pain treatments: an interview with Dr Kieran O’Sullivan

Back pain is exceptionally common. In fact, to not experience back pain at some point of your life would be thoroughly abnormal. Experiencing back pain is like becoming tired or becoming sad; we don’t necessarily like it, but it’s perfectly common. [More]
Oncotype DX assay linked to decrease in chemotherapy use in younger patients

Oncotype DX assay linked to decrease in chemotherapy use in younger patients

In what's believed to be one of the largest population-based studies of Oncotype DX ever conducted, researchers at The University of Texas MD Anderson Cancer Center have found that the commercial diagnostic tool, Oncotype DX, was associated with a decrease in chemotherapy use in younger patients, but not in those over 66 years of age. [More]
Study sheds light on clinical and biological characteristics of male breast cancer

Study sheds light on clinical and biological characteristics of male breast cancer

Results of the EORTC10085/TBCRC/BIG/NABCG International Male Breast Cancer Program conducted in both Europe and in the United States and presented at the 2014 San Antonio Breast Cancer Symposium found significant improvement in survival for men with breast cancer, but this improvement was not as good as that observed for women. [More]
Genomic Health reports positive results from Oncotype DX clinical study in women with DCIS

Genomic Health reports positive results from Oncotype DX clinical study in women with DCIS

Genomic Health, Inc. today announced positive results from the second large clinical validation study of Oncotype DX in patients with a pre-invasive form of breast cancer known as DCIS (ductal carcinoma in situ). [More]
New statistical model enables better identification of different cell types in solid tumors

New statistical model enables better identification of different cell types in solid tumors

A new statistical model developed by a research team at Worcester Polytechnic Institute may enable physicians to create personalized cancer treatments for patients based on the specific genetic mutations found in their tumors. [More]
Three studies reveal effects of blocking androgen receptors in breast cancer

Three studies reveal effects of blocking androgen receptors in breast cancer

Three studies presented by University of Colorado Cancer Center researchers at the San Antonio Breast Cancer Symposium 2014 demonstrate the effects of blocking androgen receptors in breast cancer. [More]
Preventive effect of tamoxifen drug for breast cancer remains virtually constant for 20 years

Preventive effect of tamoxifen drug for breast cancer remains virtually constant for 20 years

The preventive effect of breast cancer drug 'tamoxifen' remains virtually constant for at least 20 years - with rates reduced by around 30 per cent - new analysis published in The Lancet Oncology reveals. [More]
Cianna Medical's SAVI SCOUT surgical guidance system gets FDA clearance

Cianna Medical's SAVI SCOUT surgical guidance system gets FDA clearance

Cianna Medical Inc. announced today U.S. Food and Drug Administration clearance for the SAVI SCOUT surgical guidance system, a novel technology that uses real-time audible and visual indicators to give surgeons a precise way to target tissue during lumpectomy and excisional biopsy procedures. [More]