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Abide Therapeutics begins Phase 1a study of ABX-1431 investigational endocannabinoid system modulator

Abide Therapeutics begins Phase 1a study of ABX-1431 investigational endocannabinoid system modulator

Abide Therapeutics, a developer of innovative pharmaceuticals, announced today initiation of enrollment and dosing of the first subject in a Phase 1a clinical study of ABX-1431, a first-in-class, investigational endocannabinoid system modulator. [More]
Allergan agrees to acquire exclusive worldwide rights to Merck's CGRP migraine development program

Allergan agrees to acquire exclusive worldwide rights to Merck's CGRP migraine development program

Allergan plc and Merck, known as MSD outside the United States and Canada, today announced that they have entered into an agreement under which Allergan will acquire the exclusive worldwide rights to Merck's investigational small molecule oral calcitonin gene-related peptide (CGRP) receptor antagonists, which are being developed for the treatment and prevention of migraine, subject to expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (HSR). [More]
MIT researchers reveal key brainwave changes among patients receiving nitrous oxide

MIT researchers reveal key brainwave changes among patients receiving nitrous oxide

Nitrous oxide, commonly known as "laughing gas," has been used in anesthesiology practice since the 1800s, but the way it works to create altered states is not well understood. In a study published this week in Clinical Neurophysiology, MIT researchers reveal some key brainwave changes among patients receiving the drug. [More]
Akcea Therapeutics obtains FDA Orphan Drug Designation for volanesorsen

Akcea Therapeutics obtains FDA Orphan Drug Designation for volanesorsen

Akcea Therapeutics, a wholly-owned subsidiary of Isis Pharmaceuticals, Inc., announced today that the U.S. Food and Drug Administration has granted Orphan Drug Designation to volanesorsen (ISIS-APOCIIIRx) for the treatment of patients with Familial Chylomicronemia Syndrome (FCS). [More]
Study: New test may help predict effectiveness of biologic drugs in RA patients

Study: New test may help predict effectiveness of biologic drugs in RA patients

A study of 311 patients by The University of Manchester has found that it may be possible to predict early which rheumatoid arthritis (RA) patients will fail to respond to the biologic drugs given to treat them. [More]
Two new studies show that fecal transplantation may help fight against ulcerative colitis

Two new studies show that fecal transplantation may help fight against ulcerative colitis

Two new studies led by researchers from the Farncombe Family Digestive Health Research Institute at McMaster University show that transplantation of fecal matter may be a useful tool in the fight against ulcerative colitis (UC). [More]
Scientists find way to create therapeutic heat to treat people suffering from chronic muscle pain

Scientists find way to create therapeutic heat to treat people suffering from chronic muscle pain

If you suffer from chronic muscle pain a doctor will likely recommend for you to apply heat to the injury. But how do you effectively wrap that heat around a joint? Korean Scientists at the Center for Nanoparticle Research, Institute for Basic Science in Seoul, along with an international team, have come up with an ingenious way of creating therapeutic heat in a light, flexible design. [More]
Afamelanotide treatment improves quality of life in people with erythropoietic protoporphyria

Afamelanotide treatment improves quality of life in people with erythropoietic protoporphyria

A novel synthetic hormone that makes certain skin cells produce more melanin significantly increases pain-free sun exposure in people with erythropoietic protoporphyria, a rare, genetic disorder resulting in excruciating pain within minutes of sun exposure. [More]
Galderma obtains FDA approval for Restylane Lyft to restore structure to the cheeks and midface area

Galderma obtains FDA approval for Restylane Lyft to restore structure to the cheeks and midface area

Galderma, a global healthcare company focused on skin health, announced today that it has received U.S. Food and Drug Administration approval to market Restylane Lyft for cheek augmentation and the correction of age-related midface contour deficiencies in patients over the age of 21. [More]
Study demonstrates the important role of placebo effect in medical care

Study demonstrates the important role of placebo effect in medical care

The "placebo effect" is often described as events that occur when patients show improvement from treatments that contain no active ingredients. [More]
Results from Phase 3 study evaluating safety and efficacy of Zalviso published in Anesthesiology

Results from Phase 3 study evaluating safety and efficacy of Zalviso published in Anesthesiology

AcelRx Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of acute and breakthrough pain, today announced that results from the IAP311 study have been published in Anesthesiology. [More]
Using multiple pharmacies to fill prescriptions associated with opioid overdoses

Using multiple pharmacies to fill prescriptions associated with opioid overdoses

A study conducted in the state of Washington and reported in The Journal of Pain showed that almost half of deaths attributed to prescription opioids were Medicaid recipients, and using multiple pharmacies to fill prescriptions is linked with opioid overdoses. [More]
1 in 4 people with histories of nicotine use, substance abuse likely to use opioid painkillers long-term

1 in 4 people with histories of nicotine use, substance abuse likely to use opioid painkillers long-term

Opioid painkiller addiction and accidental overdoses have become far too common across the United States. To try to identify who is most at risk, Mayo Clinic researchers studied how many patients prescribed an opioid painkiller for the first time progressed to long-term prescriptions. The answer: 1 in 4. People with histories of tobacco use and substance abuse were likeliest to use opioid painkillers long-term. [More]
Study provides insights into the cause of irritable bowel syndrome

Study provides insights into the cause of irritable bowel syndrome

A team comprised of scientists at VIB, KU Leuven and UZ Leuven has made significant progress in uncovering the connection between psychological factors and the immune system. Their findings are based on an investigation of a massive drinking water contamination incident in Belgium in 2010, and are now published in the leading international medical journal Gut. [More]
Educational messages about naloxone's lifesaving benefits can bolster support for its use

Educational messages about naloxone's lifesaving benefits can bolster support for its use

While most Americans do not support policies designed to increase distribution of naloxone - a medication that reverses the effects of a drug overdose - certain types of educational messages about its lifesaving benefits may bolster support for its use, new Johns Hopkins Bloomberg School of Public Health research suggests. [More]
UTHealth researchers discover new light-activated proteins that work as 'off switches' for brain cells

UTHealth researchers discover new light-activated proteins that work as 'off switches' for brain cells

Light switches for neurons have made enormous contributions to brain research by giving investigators access to "on switches" for brain cells. But, finding "off switches" has been much more challenging. [More]
Penn State Health, CHI complete transfer of St. Joseph Regional Health Network ownership

Penn State Health, CHI complete transfer of St. Joseph Regional Health Network ownership

Penn State Health and Catholic Health Initiatives have completed the transfer of ownership of CHI's affiliate, St. Joseph Regional Health Network (St. Joseph) in Reading, Pa., to Penn State Health. [More]
Women with 'female athlete triad' at greater risk of bone stress injuries

Women with 'female athlete triad' at greater risk of bone stress injuries

Participation in sports by women and girls has increased from 310,000 individuals in 1971 to 3.37 million in 2010. At the same time, sports-related injuries among female athletes have skyrocketed. [More]
Two-thirds of patients with T4a larynx cancer not receiving total laryngectomy

Two-thirds of patients with T4a larynx cancer not receiving total laryngectomy

Despite findings of previous studies and published guidelines, nearly two-thirds of patients with T4a larynx ("voice box") cancer are not receiving a total laryngectomy (surgical removal of the larynx), the recommended form of treatment, and as a result, have significantly worse survival rates versus those treated with a total laryngectomy, a new study published in the International Journal of Radiation Oncology, Biology and Physics by experts at Penn Medicine found. [More]
Ambulance services should be assessed on reassurance and response time

Ambulance services should be assessed on reassurance and response time

Ambulance services should be assessed on how reassured patients and their families feel during an emergency as well as on response times, researchers have found. [More]
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