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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

TREM2 protein may help slow progression of multiple sclerosis, Alzheimer's disease

Highlighting a potential target in the treatment of multiple sclerosis (MS) and Alzheimer's disease, new research suggests that triggering a protein found on the surface of brain cells may help slow the progression of these and other neurological diseases.

3 Mar 2015

MIT researchers develop new nanodevice that can help overcome drug resistance

Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by MIT researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.

3 Mar 2015

BUSM researchers discover genes involved in formation of lung tumors

The lung transcription factor Nkx2-1 is an important gene regulating lung formation and normal respiratory functions after birth. Alterations in the expression of this transcription factor can lead to diseases such as lung interstitial disease, post-natal respiratory distress and lung cancer.

3 Mar 2015

Caltech researchers reveal new information that could help fight against hookworms

Tiny parasitic hookworms infect nearly half a billion people worldwide--almost exclusively in developing countries--causing health problems ranging from gastrointestinal issues to cognitive impairment and stunted growth in children. By sequencing and analyzing the genome of one particular hookworm species, Caltech researchers have uncovered new information that could aid the fight against these parasites.

3 Mar 2015

Scientists sequence genome of hookworm

In an advance that may potentially lead to new treatments for parasitic hookworms, scientists at the University of Massachusetts Medical School and Cornell University have sequenced the genome of the hookworm, Ancylostoma ceylanicum.

3 Mar 2015

Sall4 protein helps fix DNA damage

A protein that helps embryonic stem cells (ESCs) retain their identity also promotes DNA repair, according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a similar role in cancer cells, helping them fix DNA damage to survive chemotherapy.

3 Mar 2015

Toning down TREM2 receptor's activity may help prevent neurodegeneration in AD patients

Tackling brain inflammation ameliorates Alzheimer's disease (AD), according to a study published in The Journal of Experimental Medicine.

3 Mar 2015

People with diabetes more prone to depression, anxiety

People with diabetes are more prone to anxiety and depression than those with other chronic diseases that require similar levels of management. The reasons for this aren't well understood, but Joslin Diabetes Center researchers have discovered one potential explanation.

2 Mar 2015

U-M researchers reveal key role of two enzymes that help the body to remove cholesterol, other lipids

With the aid of X-ray crystallography, researchers at the University of Michigan have revealed the structures of two closely related enzymes that play essential roles in the body's ability to metabolize excess lipids, including cholesterol.

2 Mar 2015

Study details a new pathway for tumor formation

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine (SVM) have identified the biological mechanism that may give some cancer cells the ability to form tumors in dogs.

2 Mar 2015

Findings may explain why HIV cure strategies have failed

A major hurdle to curing people of HIV infection is the way the virus hides in a reservoir composed primarily of dormant immune cells.

2 Mar 2015

Scientists discover amyloid accumulation in young human brains

Amyloid -- an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease -- starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined, reports a surprising new Northwestern Medicine study.

2 Mar 2015

CLL patients discontinue ibrutinib drug due to disease progression during clinical trials

About 10 percent of patients with chronic lymphocytic leukemia (CLL) discontinued therapy with the Bruton tyrosine kinase (BTK) inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online in JAMA Oncology.

28 Feb 2015

CSL Behring donates protein therapies to World Federation of Hemophilia

In recognition of Rare Disease Day and as part of its ongoing commitment to the global bleeding disorders community, CSL Behring announced today that it is donating 2 million international units (IUs) of protein therapies to the World Federation of Hemophilia.

28 Feb 2015

New technology could help researchers advance blood biomarker capabilities for TBI

New technology being introduced at NYU Langone Medical Center could help researchers advance blood biomarker capabilities that show changes in low concentrations of specific proteins present following a neurological injury.

28 Feb 2015

New pharmacological compounds block nerve cell damage in mouse models of MS

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

28 Feb 2015

Feast-or-famine diet may extend lifespan, improve age-related diseases

University of Florida Health researchers have found that putting people on a feast-or-famine diet may mimic some of the benefits of fasting, and that adding antioxidant supplements may counteract those benefits.

27 Feb 2015

NIAID partners with Liberian government to test ZMapp drug for Ebola virus disease

In partnership with the Liberian government, the National Institute of Allergy and Infectious Diseases today launched a clinical trial to obtain safety and efficacy data on the investigational drug ZMapp as a treatment for Ebola virus disease. The study, which will be conducted in Liberia and the United States, is a randomized controlled trial enrolling adults and children with known Ebola virus infection.

27 Feb 2015

New tool provides molecular details about how mutations affect cellular processes

Today in the journal Nature Methods, the laboratory headed by ICREA researcher Patrick Aloy, at the Institute for Research in Biomedicine, presents a computational tool that allows a greater understanding of the genetic causes of complex diseases such as cancer, Alzheimer's and diabetes.

27 Feb 2015

UConn chemists develop more advanced peanut allergy test

Current peanut allergy tests are not very reliable when it comes to diagnosing the severity of an individual's allergic reaction, which can range from hives to life-threatening anaphylactic shock.

27 Feb 2015

Protein News and Research

Further Reading

TREM2 protein may help slow progression of multiple sclerosis, Alzheimer's disease

MIT researchers develop new nanodevice that can help overcome drug resistance

BUSM researchers discover genes involved in formation of lung tumors

Caltech researchers reveal new information that could help fight against hookworms

Scientists sequence genome of hookworm

Sall4 protein helps fix DNA damage

Toning down TREM2 receptor's activity may help prevent neurodegeneration in AD patients

People with diabetes more prone to depression, anxiety

U-M researchers reveal key role of two enzymes that help the body to remove cholesterol, other lipids

Study details a new pathway for tumor formation

Findings may explain why HIV cure strategies have failed

Scientists discover amyloid accumulation in young human brains

CLL patients discontinue ibrutinib drug due to disease progression during clinical trials

CSL Behring donates protein therapies to World Federation of Hemophilia

New technology could help researchers advance blood biomarker capabilities for TBI

New pharmacological compounds block nerve cell damage in mouse models of MS

Feast-or-famine diet may extend lifespan, improve age-related diseases

NIAID partners with Liberian government to test ZMapp drug for Ebola virus disease

New tool provides molecular details about how mutations affect cellular processes

UConn chemists develop more advanced peanut allergy test

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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