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Testosterone is a steroid hormone from the androgen group. In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands
Nomogram aids management of boys with constitutional delay in growth and puberty

Nomogram aids management of boys with constitutional delay in growth and puberty

A puberty nomogram is better than the classical criteria for identifying boys with constitutional delay in growth and puberty, report researchers. [More]
Study finds no evidence that testosterone replacement therapy increases cardiovascular risk

Study finds no evidence that testosterone replacement therapy increases cardiovascular risk

Fears of a link between testosterone replacement therapy and cardiovascular risk are misplaced, according to a review published in this month's Mayo Clinic Proceedings. The therapy has come under widespread scrutiny in recent months, including by a federal Food and Drug Administration panel convened last fall. [More]
Androgen receptor in prostate cancer cells can activate different gene set when bound to antiandrogens

Androgen receptor in prostate cancer cells can activate different gene set when bound to antiandrogens

The androgen receptor in prostate cancer cells can activate different sets of genes depending on whether it binds with an androgen hormone or an antiandrogen drug, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. [More]
Study: Prostate cancer drug stabilizes memory loss for a year in women with Alzheimer's disease

Study: Prostate cancer drug stabilizes memory loss for a year in women with Alzheimer's disease

Women with Alzheimer's disease showed stable cognition for a year when a drug that is more commonly used to treat advanced prostate cancer was added to their drug regimen, according to a new study from researchers at the University of Wisconsin-Madison. [More]

Fast HPLC screening methods used to detect steroids

As the importance of steroids in the regulation of bioprocesses has increased so has the demand for fast screening methods for their detection. HPLC is a highly regarded analytical technique for pharmaceutical applications due to its unrivalled analytical validation characteristics; including accuracy, precision, limit of detection, specificity, linearity and range, and ruggedness. [More]
Personal gender identity of every human being is reflected in the structure of brain networks

Personal gender identity of every human being is reflected in the structure of brain networks

Our sense of belonging to the male or female gender is an inherent component of the human identity perception. As a general rule, gender identity and physical sex coincide. If this is not the case, one refers to trans-identity or transsexuality. In a current study, brain researcher Georg S. Kanz of the University Clinic for Psychiatry and Psychotherapy of the MedUni Vienna was able to demonstrate that the very personal gender identity of every human being is reflected and verifiable in the cross-links between brain regions. [More]
Testosterone therapy suppresses some advanced prostate cancers, find Johns Hopkins scientists

Testosterone therapy suppresses some advanced prostate cancers, find Johns Hopkins scientists

In a surprising paradox, the male hormone testosterone, generally thought to be a feeder of prostate cancer, has been found to suppress some advanced prostate cancers and also may reverse resistance to testosterone-blocking drugs used to treat prostate cancer. [More]
Adding radiation treatment to hormone therapy saves older men with prostate cancer

Adding radiation treatment to hormone therapy saves older men with prostate cancer

Adding radiation treatment to hormone therapy saves more lives among older men with locally advanced prostate therapy than hormone therapy alone, according to a new study in the Journal of Clinical Oncology this week from Penn Medicine researchers. [More]
Even men undergo hormonal changes on way to fatherhood, study finds

Even men undergo hormonal changes on way to fatherhood, study finds

Impending fatherhood can lower two hormones--testosterone and estradiol--for men, even before their babies are born, a new University of Michigan study found. [More]
Sensitive toxicity test aims to detect dangerous side effects in pharmaceutical development

Sensitive toxicity test aims to detect dangerous side effects in pharmaceutical development

Because of undetected toxicity problems, about a third of prescription drugs approved in the U.S. are withdrawn from the market or require added warning labels limiting their use. An exceptionally sensitive toxicity test invented at the University of Utah could make it possible to uncover more of these dangerous side effects early in pharmaceutical development so that fewer patients are given unsafe drugs. [More]
Male hormone testosterone may increase risk of colon cancer

Male hormone testosterone may increase risk of colon cancer

Previous cancer research has revealed that women are less likely than men to suffer from non-sex specific cancers such as cancer of the colon, pancreas and stomach. Scientists theorized that perhaps this trend was due to a protecting effect created by female hormones, such as estrogen, that help prevent tumors from forming. Now, researchers at the University of Missouri have found evidence suggesting that the male hormone testosterone may actually be a contributing factor in the formation of colon cancer tumors. [More]
Endocrinologist examines benefits and harms of testosterone therapy

Endocrinologist examines benefits and harms of testosterone therapy

An article in the latest edition of Australian Prescriber looks at the prescribing of testosterone, often used for ‘male menopause’ symptoms such as reduced energy, poor concentration and increased body fat. Over the past decade there has been a steep rise in the amount of testosterone dispensed in Australia and globally. [More]
Study: Common prostate cancer therapy exposes low-risk patients to more adverse side effects

Study: Common prostate cancer therapy exposes low-risk patients to more adverse side effects

A common prostate cancer therapy should not be used in men whose cancer has not spread beyond the prostate, according to a new study led by researchers at Henry Ford Hospital. [More]
Exome sequencing refines 46,XY DSD diagnosis

Exome sequencing refines 46,XY DSD diagnosis

Exome sequencing can identify a likely genetic cause of 46,XY disorders of sex development in about a third of cases, report researchers. [More]
Higher surge of testosterone in competition not tied to winning, shows study

Higher surge of testosterone in competition not tied to winning, shows study

A higher surge of testosterone in competition, the so-called "winner effect," is not actually related to winning, suggests a new study of intercollegiate cross country runners. [More]
Long-term T therapy in hypogonadal men is safe, does not increase PCa risk, study finds

Long-term T therapy in hypogonadal men is safe, does not increase PCa risk, study finds

Testosterone (T) therapy is routinely used in men with hypogonadism, a condition in which diminished function of the gonads occurs. Although there is no evidence that T therapy increases the risk of prostate cancer (PCa), there are still concerns and a paucity of long-term data. [More]
VeraVia releases information to help men achieve better weight loss strategy

VeraVia releases information to help men achieve better weight loss strategy

A recent study published in the British Journal of General Practice found that physicians have difficulty visually diagnosing obesity in men. San Diego fitness retreat VeraVia has released information for men to help them understand how their own weight loss differs from women. VeraVia founder and CEO Wyatt Chapman says, "Achieving the best weight loss strategy for your body and lifestyle can be complicated. [More]
Endo announces acquisition of rights to Natesto (testosterone nasal gel)

Endo announces acquisition of rights to Natesto (testosterone nasal gel)

Endo International plc, announced today the acquisition of rights to Natesto (testosterone nasal gel), the first and only testosterone nasal gel for replacement therapy in adult males diagnosed with hypogonadism, from Trimel BioPharma SRL, a wholly-owned subsidiary of Trimel Pharmaceuticals Corporation. [More]
Auxilium Pharmaceuticals presents STENDRA clinical data for ED treatment at SMSNA Scientific Meeting

Auxilium Pharmaceuticals presents STENDRA clinical data for ED treatment at SMSNA Scientific Meeting

Auxilium Pharmaceuticals, Inc., a specialty biopharmaceutical company, today announced that data were presented regarding the use of STENDRA® (avanafil) tablets for the treatment of erectile dysfunction (ED) at the 20th Annual Fall Scientific Meeting of the Sexual Medicine Society of North America (SMSNA) held in Miami from November 20-23, 2014. [More]
Researchers obtain detailed picture of how Gas5 RNA interacts with steroid hormone receptors

Researchers obtain detailed picture of how Gas5 RNA interacts with steroid hormone receptors

It arises from what scientists previously described as "junk DNA" or "the dark matter of the genome," but this gene is definitely not junk. [More]