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Toxicology is the study of harmful interactions between chemical, physical, or biological agents and biological systems.
Using Cultrex BME 2 reduced growth factor to enable long-term culture of human hepatocytes

Using Cultrex BME 2 reduced growth factor to enable long-term culture of human hepatocytes

AMSBIO reports on the recent publication in Cell [1] by Dr Meritxell Huch, Prof Hans Clevers et al. of ground-breaking research using Cultrex BME2 reduced growth factor (organoid growth matrix) to enable long-term (>1 year) culture of genome-stable bipotent stem cells from adult human liver. These results open up new experimental avenues towards the use of human liver material expanded in vitro as an alternative cell source for disease modeling, toxicology studies, drug testing, regenerative medicine and gene therapy. [More]
New study may lead to novel drug target for treating lung cancer

New study may lead to novel drug target for treating lung cancer

A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer. [More]
Morphine after tonsillectomy may be life threatening for children

Morphine after tonsillectomy may be life threatening for children

Treating post-operative pain with morphine can cause life-threatening respiratory problems in some children who have had their tonsils and/or adenoids removed, new research has found. [More]
INRS researchers to use new specialized equipment to study environmental equity, male infertility

INRS researchers to use new specialized equipment to study environmental equity, male infertility

With the acquisition of new specialized equipment, INRS researchers Philippe Apparicio, Géraldine Delbès, and Maritza Jaramillo and their teams will be able to advance knowledge and train highly qualified people in the fields of environmental equity, reproductive toxicology, and the treatment of infections. They received a total of over $1 million from the Quebec government and the John R. Evans Leaders Fund of the Canadian Foundation for Innovation. [More]
UChicago researchers awarded NIH grants to develop novel medications for sleep apnea, asthma

UChicago researchers awarded NIH grants to develop novel medications for sleep apnea, asthma

Two research teams based at the University of Chicago have received prestigious grants from the National Institutes of Health to develop novel medications to treat sleep apnea and asthma. [More]
New study finds no correlation between opioids administered in the ER and patient satisfaction scores

New study finds no correlation between opioids administered in the ER and patient satisfaction scores

A new study co-authored by investigators at the University of Massachusetts Medical School found that there is no correlation between opioids administered in the emergency room setting and Press Ganey ED patient satisfaction scores, one of the most commonly used metrics for measuring patient satisfaction. [More]

Alere completes sale of Alere Health

Alere Inc. today announced the completion of the previously announced sale of Alere Health and its subsidiaries, which provide leading condition management, case management, wellbeing, wellness and women's and children's health services to regional and local health plans, Fortune 500 employers and state governments, to Optum for $600 million in cash. [More]
Exposure to nanoparticles can play major role in development of cardiovascular diseases

Exposure to nanoparticles can play major role in development of cardiovascular diseases

Nanoparticles, extremely tiny particles measured in billionths of a meter, are increasingly everywhere, and especially in biomedical products. Their toxicity has been researched in general terms, but now a team of Israeli scientists has for the first time found that exposure nanoparticles (NPs) of silicon dioxide (SiO2) can play a major role in the development of cardiovascular diseases when the NP cross tissue and cellular barriers and also find their way into the circulatory system. [More]
More insight into influence of obesity on distribution, elimination of drugs needed, say experts

More insight into influence of obesity on distribution, elimination of drugs needed, say experts

Doctors and pharmacists often do not take obesity into account when prescribing medication. For this, more insight into the influence of obesity on the distribution and elimination of drugs is of the utmost importance. This is emphasized by Catherijne Knibbe in the most recent issue of the Annual Review of Pharmacology and Toxicology. [More]
Palatin begins bremelanotide phase 3 study for treatment of female sexual dysfunction

Palatin begins bremelanotide phase 3 study for treatment of female sexual dysfunction

Palatin Technologies, Inc., a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical needs and commercial potential, today announced that it has started its bremelanotide pivotal registration program. [More]
Methamphetamine use may increase Parkinson's disease risk

Methamphetamine use may increase Parkinson's disease risk

In addition to incurring serious dental problems, memory loss and other physical and mental issues, methamphetamine users are three times more at risk for getting Parkinson's disease than non-illicit drug users, new research from the University of Utah and Intermountain Healthcare shows. [More]
FL118 agent shows efficacy as personalized, targeted therapy for certain cancer tumors

FL118 agent shows efficacy as personalized, targeted therapy for certain cancer tumors

A team led by Fengzhi Li, PhD, and Xinjiang Wang, PhD, of Roswell Park Cancer Institute has reported new findings regarding therapeutic targets of the novel anticancer agent FL118. Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell-survival proteins (survivin, Mcl-1, XIAP or cIAP2). [More]
New study analyses prevalence of domestic violence against pregnant women

New study analyses prevalence of domestic violence against pregnant women

A new study analyses the violent behaviours exhibited towards pregnant women. While 21% of women suffer emotional violence during pregnancy, 3.6% encounter physical or sexual violence. Furthermore, 36.1% of those who reported physical violence claimed that it happened "very often" or "daily". [More]
Researchers develop new method to track movement of carcinogenic PAHs in the human body

Researchers develop new method to track movement of carcinogenic PAHs in the human body

Researchers for the first time have developed a method to track through the human body the movement of polycyclic aromatic hydrocarbons, or PAHs, as extraordinarily tiny amounts of these potential carcinogens are biologically processed and eliminated. [More]
Alere Determine HIV-1/2 Ag/Ab Combo test receives CLIA Waiver from FDA

Alere Determine HIV-1/2 Ag/Ab Combo test receives CLIA Waiver from FDA

Alere Inc., a global leader in rapid diagnostic tests, today announced that the U.S. Food and Drug Administration (FDA) has granted CLIA (Clinical Laboratory Improvement Amendments) Waiver for the Alere Determine™ HIV-1/2 Ag/Ab Combo test. [More]
Three IU researchers receive $2.1 million to develop computational biology models of liver toxicity

Three IU researchers receive $2.1 million to develop computational biology models of liver toxicity

Three Indiana University professors have received $2.1 million to develop a computational model of acetaminophen-induced liver failure -- the leading cause of liver failure in the United States -- by using advanced microscopic and computational technologies that allow scientists to see into the liver of a living animal. [More]
Organovo, Yale collaborate to develop bioprinted tissues for surgical transplantation research

Organovo, Yale collaborate to develop bioprinted tissues for surgical transplantation research

Organovo Holdings, Inc., a three-dimensional biology company focused on delivering breakthrough 3D bioprinting technology, and Yale School of Medicine, Department of Surgery have formed a collaboration to develop bioprinted tissues for surgical transplantation research, made possible by a generous gift from the Methuselah Foundation. [More]
BioPharmX submits request for pre-IND meeting to FDA for topical antibiotic acne compound

BioPharmX submits request for pre-IND meeting to FDA for topical antibiotic acne compound

BioPharmX Corporation, a biotechnology company focused on the development of novel drug delivery products to address unmet needs in large, well-defined and underserved markets, today announced that it has submitted a request for a pre-IND (Investigational New Drug) meeting to the U.S. Food and Drug Administration for the company's topical antibiotic acne compound currently under development. [More]
Kansas State University awarded patent for a series of synthetic compounds

Kansas State University awarded patent for a series of synthetic compounds

A patent has been issued for a series of synthetic compounds developed at Kansas State University that have applications for treating cancer and other diseases that affect cell communication. [More]
Pain medicine specialist receives award for new advances in oral fluid testing

Pain medicine specialist receives award for new advances in oral fluid testing

This year's Eastern Pain Society Scientific meeting was held at Mount Sinai Beth Israel Medical Center in New York City in late October and is one of the largest meetings of pain physicians and fellows in the tri-state area. [More]