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Toxicology is the study of harmful interactions between chemical, physical, or biological agents and biological systems.
RGS2 protein plays significant role in healthy egg-sperm union in mice

RGS2 protein plays significant role in healthy egg-sperm union in mice

Researchers at the National Institutes of Health have discovered a protein that plays a vital role in healthy egg-sperm union in mice. The protein RGS2 can delay an egg's development into an embryo in order to allow time for sperm to arrive and merge with the egg in a healthy fertilization process. The embryo cannot survive without the male chromosomes. [More]
Innovative approach to treating AAT deficiency

Innovative approach to treating AAT deficiency

Researchers have demonstrated the feasibility of delivering an RNA that encodes for the protein alpha-1-antitrypsin (AAT)--which is missing or nonfunctional in the genetic disorder AAT deficiency--into cells in the laboratory, enabling the cells to produce highly functional AAT. [More]
Researchers decode molecular mechanism of fish toxin that has potential to treat cancer

Researchers decode molecular mechanism of fish toxin that has potential to treat cancer

Pathogenic bacteria develop killer machines that work very specifically and highly efficiently. Scientists from the University of Freiburg have solved the molecular mechanism of a fish toxin that could be used in the future as a medication to treat cancer. The scientists have now published their research in the journal Nature Communications. [More]
Dartmouth researchers perform first total syntheses of compounds involved in rapid cell death in leukemia

Dartmouth researchers perform first total syntheses of compounds involved in rapid cell death in leukemia

Dartmouth researchers and their colleagues have carried out the first total syntheses of certain compounds involved in excessive cell death in leukemia. [More]
Sulfur dioxide air pollutant can cause adverse effects in asthmatics

Sulfur dioxide air pollutant can cause adverse effects in asthmatics

Emissions of the air pollutant sulfur dioxide have been dramatically decreased during the past 30 years but for some people even a little inhaled sulfur dioxide may still be too much. [More]

Alere announces two transactions to further strengthen its core business strategy

Alere Inc., a global leader in rapid diagnostics, announced today two transactions that further strengthen the Company's focus on its core business strategy. [More]
FDA grants CLIA waiver for Alere i Strep A test

FDA grants CLIA waiver for Alere i Strep A test

Alere Inc., a global leader in rapid diagnostic tests, today announced that the U.S. Food and Drug Administration has granted CLIA waiver for the Alere i Strep A test. The test, which was cleared for marketing by the FDA in April 2015, is the first molecular platform that detects Group A Streptococcus (GAS) bacteria in 8 minutes or less. [More]
Novogen's Anisina granted FDA Orphan Drug Designation for neuroblastoma

Novogen's Anisina granted FDA Orphan Drug Designation for neuroblastoma

US-Australian drug discovery company, Novogen Limited, today announced that it has received notification from the U.S. Food and Drug Administration that its chemotherapy candidate drug, Anisina, has been granted Orphan Drug Designation for neuroblastoma. [More]
Hospitalization rates higher among people who live near hydraulic fracturing wells

Hospitalization rates higher among people who live near hydraulic fracturing wells

Hospitalizations for heart conditions, neurological illness, and other conditions were higher among people who live near unconventional gas and oil drilling (hydraulic fracturing), according to new research from the University of Pennsylvania and Columbia University published this week in PLOS ONE. [More]
Novel gene therapy control system regulates expression of therapeutic transgenes

Novel gene therapy control system regulates expression of therapeutic transgenes

Korean researchers have described a novel control system to regulate the expression of a therapeutic transgene by targeting the passenger strand of a microRNA (miR-122) linked to the transgene. [More]
Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

Study shows that Anisina has potential to improve effectiveness of chemotherapy in children with cancer

US-Australian drug discovery company, Novogen Limited, today announced details of an in vivo proof of concept study that demonstrates their lead anti-tropomyosin drug candidate, Anisina, has the potential to improve the effectiveness of chemotherapy in children and reduce life-long side-effects. [More]
Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Elsevier, NCI implement two-way linking between research articles on ScienceDirect and datasets in caNanoLab

Elsevier, a world-leading provider of scientific, technical and medical information products and services, and the US National Cancer Institute, a world-leading institute for cancer research, today announced that they have implemented two-way linking between research articles on ScienceDirect and datasets stored in NCI's cancer Nanotechnology Laboratory (caNanoLab) data portal. [More]
UC Davis scientists identify significant driver of neuropathic pain

UC Davis scientists identify significant driver of neuropathic pain

Scientists at the University of California, Davis, have identified a key mechanism in neuropathic pain. The discovery could eventually benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis or other conditions that cause nerve damage. [More]
Discovery could pave way to new treatments for malaria

Discovery could pave way to new treatments for malaria

Scientists have discovered new ways in which the malaria parasite survives in the blood stream of its victims, a discovery that could pave the way to new treatments for the disease. [More]
CTI Biotechnology implements Xybion's Pristima 7 Preclinical Suite

CTI Biotechnology implements Xybion's Pristima 7 Preclinical Suite

Xybion Corporation, leading provider of preclinical R&D solutions announced today that CTI Biotechnology in Suzhou, China has implemented Xybion's Pristima 7 Preclinical Suite. Pristima® was selected after an exhaustive evaluation of top selling preclinical software systems on the market. [More]
Tiny aquatic flatworms could replace existing animal models used in neurotoxicity tests

Tiny aquatic flatworms could replace existing animal models used in neurotoxicity tests

Laboratories that test chemicals for neurological toxicity could reduce their use of laboratory mice and rats by replacing these animal models with tiny aquatic flatworms known as freshwater planarians. [More]
E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

Investigators from Dartmouth's Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer. [More]
UB study sheds light on the molecular basis of cocaine addiction

UB study sheds light on the molecular basis of cocaine addiction

Researchers at the University at Buffalo have discovered a previously unknown neural pathway that can regulate changes made in the brain due to cocaine use, providing new insight into the molecular basis of cocaine addiction. [More]
ESCMID introduces two new study groups to create networks for forensic and veterinary microbiology

ESCMID introduces two new study groups to create networks for forensic and veterinary microbiology

The European Society of Clinical Microbiology and Infectious Diseases launched two new study groups; the Forensic and Postmortem Microbiology Study Group and the Veterinary Microbiology Study Group. [More]
Bio-Techne to acquire 100% ownership of Cliniqa

Bio-Techne to acquire 100% ownership of Cliniqa

Bio-Techne Corporation announced today that it has agreed to acquire 100% ownership of Cliniqa Corporation. Cliniqa specializes in the manufacturing and commercialization of quality controls and calibrators as well as bulk reagents used in the clinical diagnostic market. [More]
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