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Toxicology is the study of harmful interactions between chemical, physical, or biological agents and biological systems.
Predictive power of computational toxicology demonstrated with crowd-sources scientific challenge

Predictive power of computational toxicology demonstrated with crowd-sources scientific challenge

Results of the Systems Toxicology Computational Challenge have demonstrated how transcriptomics information present in the blood can be used to predict whether people have been exposed or not exposed to specific toxicants. [More]
New multicomponent reactions to develop active compounds against sleeping sickness

New multicomponent reactions to develop active compounds against sleeping sickness

Multicomponent reactions are protocols that ease the chemical synthesis of new compounds, and are particularly important to gain molecules with biological activity as therapeutic agents against several pathogens. [More]
Researchers make successful vaccine formulation that targets proteins linked to Alzheimer’s disease

Researchers make successful vaccine formulation that targets proteins linked to Alzheimer’s disease

With more than 7.5 million new cases of Alzheimer’s disease a year, the race to find a vaccine and effective treatment for dementia is growing by the day. [More]
Hops extract activates chemical pathway in cells to help prevent breast cancer

Hops extract activates chemical pathway in cells to help prevent breast cancer

An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the UIC/NIH Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago. [More]
Food additive tBHQ may be linked to increase in food allergies

Food additive tBHQ may be linked to increase in food allergies

A Michigan State University researcher has found that a common food additive may be linked to a rise in food allergies. [More]
Prenatal butylparaben exposure causes various endocrine disrupting effects in rats

Prenatal butylparaben exposure causes various endocrine disrupting effects in rats

Research suggests that butylparaben - which is used in cosmetics and skin care products such as sunscreen - have more endocrine disrupting effects than previously thought. [More]
Buck researchers find new way for possible treatment of AMD

Buck researchers find new way for possible treatment of AMD

Buck researchers boosted the potency of a broccoli-related compound by ten times and identified it as a possible treatment for age-related macular degeneration (AMD), the leading cause of vision loss affecting more than 10 million older Americans. [More]
WRAIR collaborates with Sanofi Pasteur to develop ZPIV vaccine candidate

WRAIR collaborates with Sanofi Pasteur to develop ZPIV vaccine candidate

The Walter Reed Army Institute of Research announces a Cooperative Research and Development Agreement for the development of a Zika vaccine candidate with Sanofi Pasteur, the vaccines division of Sanofi. [More]
Environmental toxins affect children's brain development, experts agree

Environmental toxins affect children's brain development, experts agree

An unprecedented alliance of leading scientists, health professionals, and children's and environmental health advocates agree for the first time that today's scientific evidence supports a link between exposures to toxic chemicals in air, water, food and everyday products and children's risks for neurodevelopmental disorders. [More]
KIT researchers develop 3D prostate model based on cryogels

KIT researchers develop 3D prostate model based on cryogels

A team of researchers led by Dr. Friederike J. Gruhl and Professor Andrew C. B. Cato at Karlsruhe Institute of Technology are developing a three-dimensional model for prostate cancer research based on cryogels. [More]
Mutant fruit flies provide insight into origins of Parkinson's disease

Mutant fruit flies provide insight into origins of Parkinson's disease

The neurodegeneration that occurs in Parkinson’s disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a study in fruit flies. [More]
Researchers use wristband sensors to detect how opioid users in emergency room reacted to dosages

Researchers use wristband sensors to detect how opioid users in emergency room reacted to dosages

There is merit in looking at the use of wearable biosensors to detect whether opioid users stay focused on their rehabilitation programs. [More]
Metal ions released by implant wear can damage progenitors of bone-forming cells

Metal ions released by implant wear can damage progenitors of bone-forming cells

In metal-on-metal pairings, both the shell and head of an implant consist of a cobalt-chromium-molybdenum alloy. The release of metal ions into the body has been reported as a result of implant wear. Bone loss (osteolysis) was observed in many cases. [More]
Hops show promise in reducing breast cancer risk

Hops show promise in reducing breast cancer risk

Hops, the flower cones used in beer-making, are also found in dietary supplements designed to help treat post-menopausal symptoms and other conditions. Scientists are now investigating whether an extract from the plant could also help fend off breast cancer. [More]
Highly efficient bacterial agent could improve treatment of Wilson disease

Highly efficient bacterial agent could improve treatment of Wilson disease

In the 'Journal of Clinical Investigation', scientists at the Helmholtz Zentrum München describe a small peptide that very efficiently binds excess copper from liver cells. This molecule comes from a bacterium's bag of tricks and could be suitable for treating Wilson disease. [More]
E-cigarette use modifies gene expression important for upper airway immune defense

E-cigarette use modifies gene expression important for upper airway immune defense

When we smoke cigarettes, dozens of genes important for immune defense are altered in the epithelial cells that line the respiratory tract. Several of these changes likely increase the risk of bacterial infections, viruses, and inflammation. [More]
Scientists study fundamentals of tumour surveillance by immune system in mice models

Scientists study fundamentals of tumour surveillance by immune system in mice models

The body's defences detect and eliminate not only pathogens but also tumour cells. Natural killer cells (NK-Cells) are specifically activated by chemical messengers, the Cytokines, to seek and destroy tumour cells. [More]
Endocrine Society members advocate science-based policies to address danger of EDCs

Endocrine Society members advocate science-based policies to address danger of EDCs

To protect human health, Endocrine Society members called on the European Commission to adopt science-based policies for regulating endocrine-disrupting chemicals in an opinion piece published today in The Lancet Diabetes & Endocrinology. [More]
Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

As individuals and as populations our risks of getting diseases are determined partly genetically and partly from the environment that we live in. An important part of that environment that mediates between the outside world and the inside world of our bodies is the microbiome. [More]
Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

The metabolite of a drug that is helping patients battle multiple sclerosis appears to significantly slow the onset of Parkinson's disease, researchers say. [More]
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