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Toxicology is the study of harmful interactions between chemical, physical, or biological agents and biological systems.
Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

A study by researchers at Marshall University Joan C. Edwards School of Medicine has found that blocking the blood supply of small cell lung cancer tumors may help reduce their growth and delay the regrowth process after treatment. Small cell lung cancer is considered the most lethal of all lung cancers. [More]
Researchers demonstrate novel method for imaging engineered nanoparticles in tissues

Researchers demonstrate novel method for imaging engineered nanoparticles in tissues

As a testament to Governor Andrew Cuomo’s leadership in developing an unparalleled research and development ecosystem in New York State, Sara Brenner, MD, MPH and her colleagues at SUNY Polytechnic Institute (SUNY Poly), the George Washington School of Medicine and Health Sciences, and Stony Brook University have demonstrated a novel method for the rapid visualization and identification of engineered nanoparticles in tissues. [More]
Researchers develop unique approach to track, label neural stem cells

Researchers develop unique approach to track, label neural stem cells

An overwhelming number of researchers still struggle within the black hole of the effectiveness and safety of stem cell therapy for neurological diseases. While the complexity of understanding how neurons grow, connect and function has long been studied, it remains a mystery, one that graduate student Forrest Goodfellow in the University of Georgia Regenerative Bioscience Center is helping unravel. [More]
Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients--with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. [More]
Cell-based tests reveal no activity in cells exposed to vapour from Vype ePen

Cell-based tests reveal no activity in cells exposed to vapour from Vype ePen

A series of cell-based tests developed to compare the biological impact of cigarette smoke with e-cigarette vapour revealed no activity in cells exposed to vapour from Vype ePen, a commercially available e-cigarette. [More]
Scientists discover molecular switch that can burn off excess pounds

Scientists discover molecular switch that can burn off excess pounds

The number of overweight people is increasing worldwide -- and thus the risk of developing diabetes or cardiovascular disease. [More]

Ketamine appears to be safe, effective for difficult-to-sedate ER patients

For the small segment of the emergency population whose acute behavioral disturbance does not respond to traditional sedation, ketamine appears to be effective and safe, according to an Australian study published online last Thursday in Annals of Emergency Medicine ("Ketamine for Difficult to Sedate Severe Acute Behavioral Disturbance in the Emergency Department"). [More]
NK cells produce VEGF-A that promotes tumor growth

NK cells produce VEGF-A that promotes tumor growth

The immune system protects the body against cancer cells. The Elimination of cancer cells is an important task of NK cells. For NK cells to function properly, they require the activator STAT5. [More]

Johns Hopkins researchers create map of world's chemical landscape

Researchers from the Johns Hopkins Bloomberg School of Public Health have created a map of the world's chemical landscape, a catalogue of 10,000 chemicals for which there is available safety data that they say can predict the toxicity of many of the 90,000 or more other substances in consumer products for which there is no such information. [More]
Molecular imaging and radiochemistry: the importance of instrumentation. An interview with Professor Björn Wängler

Molecular imaging and radiochemistry: the importance of instrumentation. An interview with Professor Björn Wängler

I’m Björn Wängler, Professor for Molecular Imaging and Radiochemistry at the medical faculty Mannheim of Heidelberg University. I’m a radiopharmaceutical chemist by background and completed my PhD in 2004 at the University of Mainz. [More]
Framework for improving chemical hazard assessment without animals

Framework for improving chemical hazard assessment without animals

A new paper published in Regulatory Toxicology and Pharmacology, co-authored by the Physicians Committee for Responsible Medicine, calls for ongoing development and regulatory acceptance of adverse outcome pathways (AOPs), a framework for improving chemical hazard assessment by prioritizing modern test methods that reduce animal use. [More]
Researchers developing new methods to better analyze effects of e-cig flavorings

Researchers developing new methods to better analyze effects of e-cig flavorings

Faculty and student researchers at Rochester Institute of Technology's National Technical Institute for the Deaf are developing methods to better analyze the effects of flavorings used in electronic cigarettes (e-cigs). [More]
Auranofin drug could improve prognosis for ovarian cancer patients exhibiting BRCA1 deficiency

Auranofin drug could improve prognosis for ovarian cancer patients exhibiting BRCA1 deficiency

An anti-rheumatic drug could improve the prognosis for ovarian cancer patients exhibiting a deficiency of the DNA repair protein BRCA1, a study suggests. [More]
E-cigarettes share similar short-term safety profile as Nicorette products

E-cigarettes share similar short-term safety profile as Nicorette products

A new study, published in the Journal of Regulatory Toxicology and Pharmacology, found that e-cigarettes share a similar short-term safety profile as Nicorette products and are comparable in reducing tobacco withdrawal symptoms. [More]
Scientists develop a method for cell replacement in diseased vessels

Scientists develop a method for cell replacement in diseased vessels

In industrialized countries, a particularly high number of people suffer from arteriosclerosis -- with fatal consequences: Deposits in the arteries lead to strokes and heart attacks. A team of researchers under the leadership of the University of Bonn has now developed a method for guiding replacement cells to diseased vascular segments using nanoparticles. [More]
Researchers suggest microorganisms in the womb set stage for health problems later in life

Researchers suggest microorganisms in the womb set stage for health problems later in life

Researchers review importance of microorganisms that exist in the gut, suggesting perturbation of the environment during pregnancy, delivery and early infancy could impact the developing baby's early microbiome and set the stage for health problems later in life. The term "microbiome" refers to the trillions of organisms we harbor, on our skin and within our respiratory and gastrointestinal tracts. [More]
Medication poisoning threatens young children in poor areas

Medication poisoning threatens young children in poor areas

Children younger than 5 who live in economically disadvantaged areas had a greater risk of medication poisoning that resulted in referral to a health care facility, according to scientists at the University of Pittsburgh Graduate School of Public Health and the University of California, San Diego. These areas were rural and experienced high unemployment, along with lower rates of high school graduation and lower household income. [More]
Drugs approved for various conditions also have antibiotic properties

Drugs approved for various conditions also have antibiotic properties

A number of drugs already approved to treat parasitic infections, cancers, infertility and other conditions also show promise as antibiotic agents against staph and tuberculosis infections, according to a new study by University of Illinois chemists and collaborators. Because these agents act against multiple targets within the bacteria, it may be harder for bacteria to develop resistance. [More]

New article explores harmful algal blooms and their impact on public health, environment

Harmful algal blooms (HABs) occur naturally, but their outbreaks are influenced by climate change and droughts, nutrient enrichment and manmade factors, such as contaminants from sewage and stormwater discharge, natural resource extraction or agricultural runoff, to name a few. [More]
Recreational drug and alcohol use can increase risk of poisoning-related hospital admissions

Recreational drug and alcohol use can increase risk of poisoning-related hospital admissions

Poisonings from recreational drug and alcohol use account for 9 percent of all poisoning-related hospital admissions, says a new University of Sydney study revealing that males and people under 30 are at greatest risk. [More]
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