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Toxicology is the study of harmful interactions between chemical, physical, or biological agents and biological systems.
Exposure to e-cigarette vapour induces negligible or no oxidative damage to lung epithelial cells

Exposure to e-cigarette vapour induces negligible or no oxidative damage to lung epithelial cells

E-cigarette vapour is much less harmful to lung cells than cigarette smoke. Lab tests show that, unlike tobacco smoke, which causes oxidative stress and cell death, e-cigarette vapour does not. Oxidative stress and cell death are driving factors in the development of many smoking-related diseases such as COPD and lung cancer. [More]
Prescription sleep aids may stimulate suicidal thoughts or actions

Prescription sleep aids may stimulate suicidal thoughts or actions

Prescription sleep aids appear to carry a rare risk of suicide, most typically when they cause the unexpected response of stimulating rather than quietening patients, researchers say. [More]
Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

A Duke University-led study shows how exposure to the particulate matter from cigarette smoke may affect early development in zebrafish embryos and increases the risk of neurological disorders and physical deformities. [More]
Scientists develop new method to produce embryos from non-egg cells

Scientists develop new method to produce embryos from non-egg cells

Scientists have shown for the first time that embryos can be made from non-egg cells, a discovery that challenges two centuries of received wisdom. [More]
Researchers suggest need for human studies to examine effects of cannabinoid use during pregnancy

Researchers suggest need for human studies to examine effects of cannabinoid use during pregnancy

In this new era of legalized marijuana, far too little research has been conducted on the effect of cannabis on the development of human embryos, say researchers at Georgetown University Medical Center who scoured medical literature on the topic and found what they say is worrisome animal research. [More]
OECD publishes novel knowledge management tools for advancing non-animal testing methods

OECD publishes novel knowledge management tools for advancing non-animal testing methods

The Organisation for Economic Co-operation and Development has recently published the first five adverse outcome pathways (AOP), three of which have been developed by the European Commission's science and knowledge service, the Joint Research Centre. [More]
DHA intake can prevent known trigger of lupus, study finds

DHA intake can prevent known trigger of lupus, study finds

A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders. [More]
Researchers develop new analytical capabilities to identify chemical forms of mercury in human hair

Researchers develop new analytical capabilities to identify chemical forms of mercury in human hair

Mercury is a potent neurotoxin present in our daily lives and our body can accumulate it over the years. Food consumption, such as fish and rice, is the most common source of mercury exposure. [More]
Study data does not support benefits of testosterone supplementation in men with ‘low T’

Study data does not support benefits of testosterone supplementation in men with ‘low T’

The prescription of testosterone supplementation for cardiovascular health, sexual function, physical function, mood, or cognitive function in men with "low T" is not supported by clinical trials data, conclude researchers who describe a review of more than 200 clinical trials published Sept. 21 in PLOS One. [More]
Texas A&M research shows nicotine could help protect the aging brain

Texas A&M research shows nicotine could help protect the aging brain

Everyone knows that tobacco products are bad for your health, and even the new e-cigarettes may have harmful toxins. [More]
UofL investigators to explore liver disease in comprehensive fashion

UofL investigators to explore liver disease in comprehensive fashion

Liver diseases are clinically important health problems and are generally underappreciated. The University of Louisville has brought together a critical mass of investigators to study liver diseases in a comprehensive fashion. [More]
New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials. [More]
NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Researchers at the National Center for Advancing Translational Sciences recently identified compounds that potentially can be used to inhibit Zika virus replication and reduce its ability to kill brain cells. [More]
Study finds link between childhood manganese exposure and attentional dysfunction in rodent model

Study finds link between childhood manganese exposure and attentional dysfunction in rodent model

Researchers using a rodent model of childhood manganese exposure have found that too much manganese early in development causes lasting attention deficits and other impairments. [More]
UCLA study suggests lower BPS doses damage woman's egg cells

UCLA study suggests lower BPS doses damage woman's egg cells

Bisphenol S, a chemical used to manufacture polycarbonate water bottles and many other products such as epoxy glues and cash receipts, is an increasingly common replacement for bisphenol A, the of which was discontinued because of concerns about its harmful effects on the reproductive system. [More]
Reproductive age-related changes in ovarian environment may contribute to infertility

Reproductive age-related changes in ovarian environment may contribute to infertility

Women's decreased ability to produce healthy eggs as they become older may be due to excessive scarring and inflammation in their ovaries, reports a new Northwestern Medicine study in mice. [More]
Study finds high rate of misuse of seizure and pain drug

Study finds high rate of misuse of seizure and pain drug

With increasing public attention to overdose deaths and misuse of prescription medications in the United States, researchers today presented the results of a new study looking at abuse and misuse of gabapentin, a medication used to treat seizures and relieve nerve pain often associated with shingles. [More]
Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Many gene mutations that cause neurological disorders have been identified. For example, in a rare neurological disorder such as Huntington’s disease, an autosomal dominant mutation through expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in abnormal protein production. [More]
AACC 2016: DRG International to exhibit Optimized Saliva ELISA Assays for measuring steroids

AACC 2016: DRG International to exhibit Optimized Saliva ELISA Assays for measuring steroids

DRG International, a leading international medical diagnostic company, will showcase the Newly Optimized DRG Saliva ELISA Assays at the 2016 AACC in Philadelphia, Pennsylvania from August 02-04. [More]
DRG International to display Hepcidin 25 (bioactive) HS ELISA Kit at 2016 AACC Expo

DRG International to display Hepcidin 25 (bioactive) HS ELISA Kit at 2016 AACC Expo

DRG International, a leading international medical diagnostic company, will showcase the NEW DRG Hepcidin 25 (bioactive) HS (High Sensitive) ELISA Kit (EIA-5782) at the 2016 AACC in Philadelphia, Pennsylvania from August 02-04. [More]
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