Liposome Manufacturing

The correct choice of liposome preparation method depends on the following parameters:

1. the physicochemical characteristics of the material to be entrapped and those of the liposomal ingredients;
2. the nature of the medium in which the lipid vesicles are dispersed;
3. the effective concentration of the entrapped substance and its potential toxicity;
4. additional processes involved during application/delivery of the vesicles;
5. optimum size, polydispersity and shelf-life of the vesicles for the intended application; and,
6. batch-to-batch reproducibility and possibility of large-scale production of safe and efficient liposomal products

It should be noted that formation of liposomes and nanoliposomes is not a spontaneous process. Lipid vesicles are formed when phospholipids such as lecithin are placed in water and consequently form one bilayer or a series of bilayers, each separated by water molecules, once enough energy is supplied .

Liposomes can be created by sonicating phospholipids in water are employed to produce materials for human use.

Further Reading

• What is a Liposome?
• Liposome Uses
• Liposomes and Cancer
• Liposome Research

This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Liposome" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.