Psoriasis has a large hereditary component, and many genes are associated with it, but it is not clear how those genes work together. Most of them involve the immune system, particularly the major histocompatibility complex (MHC) and T cells. The main value of genetic studies is that they identify molecular mechanisms and pathways for further study and potential drug targets.
Classic genomewide linkage analysis has identified nine locations (loci) on different chromosomes that are associated with psoriasis. They are called psoriasis susceptibility 1 through 9 (PSORS1 through PSORS9). Within those loci are genes. Many of those genes are on pathways that lead to inflammation. Certain variations (mutations) of those genes are commonly found in psoriasis.
Self-esteem and behavior can be affected by the disease. Bullying has been noted in clinical research.
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"Psoriasis"
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