Pharmaceutical science leaders from the FDA, research institutions and top pharmaceutical companies will gather at the 2004 AAPS National Biotechnology Conference, AAPS' spring annual meeting.
Research presented will highlight advances in treatment methods for AIDS, Alzheimer's and age-related blindness, providing patients and families with innovative biotechnology-based therapies. In response to AAPS members' needs, the National Biotechnology Conference is an annual event that incorporates all aspects of the pharmaceutical sciences and provides an open forum for discussion of hot industry topics.
The conference will take place in Boston, a popular biotechnology hub, at the Westin Copley Place, May 16 -18.
In its commitment to provide cutting-edge educational workshops and networking opportunities, AAPS will host sessions featuring key opinion leaders from top research firms and institutions.
The topic of Ribonucleic Acid Interference (RNAi) treatments will take center stage at the conference. RNAi is a novel technique using short molecules of RNA (siRNAs) that, when introduced into a human cell, can "turn off" or block the function of a specific gene.
This naturally occurring cellular mechanism has great promise to treat diseases such as cancer, Hepatitis C, HIV and certain eye diseases. RNAi was named Science magazine's "Breakthrough Technology of 2002" and one of Technology Review's "Top 10 Emerging Technologies for 2004." Dr. Nassim Usman of Sirna Therapeutics will present results from the company's work on an RNAi treatment for Age-Related Macular Degeneration (AMD), the leading cause of irreversible blindness in people over the age of 55. Dr. Usman will provide a timetable for the first projected RNAi clinical trials in humans.
With an estimated 40 million people worldwide living with HIV, effective treatment is in great demand. Dr. John Rossi, Professor and Chair of the City of Hope's Beckman Research Institute's Department of Molecular Biology, will be presenting conclusions to his pre-clinical data for HIV treatment.
Expanding on current HIV treatments, which use chemotherapy cocktails to attack the virus at all stages, Dr. Rossi's approach uses the latest techniques in biotechnology. Using RNAi and gene therapy, his method attacks the viral life cycle to prevent the spread of the virus to other cells and make the cells resistant to HIV.
Potential "Biogeneric" Opportunities for the Generic Pharmaceutical Industry -- In the next few years, over $10 billion in biologics, including such products as insulin and growth hormone, lose their patent protection and become available for generic competition.
While industry leaders are trying to protect their assets, the growing market could provide great opportunities for generic manufacturers. Current guidance for submitting a generic biologics are vague, and the FDA wants to proceed carefully to ensure safety and efficacy.