Hepatitis, a potentially serious disease caused by a virus that attacks the liver, is a major problem worldwide. Hepatitis A is generally foodborne, while hepatitis B and C spread primarily through parenteral or sexual routes. Hepatitis B and C can be life-long, potentially deadly chronic infections.
In studies presented today at Digestive Disease Week in New Orleans, researchers analyzed the causes of hepatitis and potential therapies that may improve care. Digestive Disease Week (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. “The hepatitis viruses, primarily A, B and C, are prevalent throughout the world, and safe and effective therapies are not available for many sufferers,” said Anna Lok, M.D., of the University of Michigan. “Once we can fully understand how these viruses cause liver damage, we can develop more effective treatments to manage and cure the disease.”
According to current estimates, coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is a major worldwide public health problem. Researchers in the VA Healthcare System examined the proportion of chronic HCV-infected patients who had been tested for HIV and related risk factors and found that improved screening programs are needed.
Data was prospectively collected in 4,364 HCV RNA positive patients undergoing evaluation for HCV therapy from 24 medical centers throughout the country over a one-year period. Of these patients, 77.9 percent had been tested for HIV, 15 percent were never tested, 6.7 percent did not know if they were tested, and 0.4 percent declined to answer. Among the HCV-infected patients who were tested for HIV, 8.4 percent were positive, 88.9 percent were negative, 2.5 percent did not know the results of the HIV test, and 0.2 percent declined to answer.
“Although the majority of our HCV-infected patients have been tested for HIV, there is still a substantial proportion who were either not tested or were tested but did not know the results,” said Edmund Bini, M.D., lead author of the study. “Better public health programs to improve HIV awareness among these patients and those at high risk of coinfection are important and should be developed.”
Patients who contract the hepatitis B virus can experience a brief, acute illness or a chronic, life-long infection. Those with chronic hepatitis B (HBV) can have serious complications such as cirrhosis, liver failure and liver cancer. Until now, it has been difficult to identify HBV patients who are likely to develop complications. A team of doctors led by Anna Lok, M.D. from the University of Michigan report today that they have developed a set of models based on laboratory test results to detect inflammation and fibrosis in the liver.
“We’re pleased that for some chronic hepatitis B patients, demographic and laboratory data enable us to predict liver injury thus avoiding the need for a liver biopsy,” said Anna Lok, M.D., lead author of the study. “Ability to determine the severity of liver injury using readily available clinical data will allow us to make more informed treatment decisions and improve quality of life for our patients.”
To identify these predictive models, researchers reviewed baseline data and liver histology from HBV patients who participated in trials of adefovir therapy for both HBeAg+ (hepatitis B e antigen positive, 494 pts) and HBeAg- (hepatitis B e antigen negative, 178 pts).