IL-7, a hormone-like protein involved in cell-cell interaction, has been associated with increased survival and expansion of T-cell acute lymphoblastic leukaemia (T-ALL).
Now, in the latest issue of the Journal of Experimental Medicine, a team of scientists, not only confirms the essential role of this protein in the disease but also, for the first time, identifies the biochemical pathway affected by IL-7 in T-ALL cells, a discovery which could lead to the development of potential new treatments for the disease.
Leukaemia is a type of blood cancer which originates from an uncontrolled growth of abnormal cells in the bone marrow (usually the white blood cells/lymphocytes). This results in very little space left for the growth of normal cells which leads to a weakened immune system. In the case of acute leukaemia the filling of the bone marrow space is extremely fast and the disease needs immediate treatment or the patient will die.
Leukaemia affects 4 out of every 100,000 people worldwide and is the most common childhood cancer. In the United States alone, every year, more than 2,000 children and almost 27,000 adults are diagnosed with the disease.
Cytokines, such as IL-7, are powerful chemical substances secreted usually, but not only, by the immune system to transmit information/instructions between cells. IL-7 is a potent growth factor for immune cells and is indispensable for normal T-cell development. Several studies have also suggested that IL-7 was involved in T-cell acute lymphoblastic leukaemia’s growth although there was no information on the mechanism(s) behind this effect.
João Barata, Angelo Cardoso, Vassiliki Boussiotis and colleagues at the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston and at the Tumour Biology Unit, Institute of Molecular Medicine, University of Lisbon, Portugal studied T-ALL cells cultured in the presence of IL-7 trying to understand, not only the real importance of this cytokine in the disease, but also the biochemical mechanism through which IL-7 mediated its effect on T-ALL.
In this paper, the team of researchers describe how they identify, for the first time, the cellular pathway in T-ALL cells which is affected by IL-7 (the pathway identified is called PI3K/Akt(PKB)), an information that can now help scientists in the search for new treatments for the disease.