Scientists in India have developed a new gel that is taken orally and is capable of delivering drugs to manage diseases often requiring an injection.
The research, published in the journal Polymer International, suggests the gel could offer a painless way of treating diabetes, ulcerative colitis, Crohn’s disease, bowel cancer, constipation and some infections, all of which require local drug delivery.
In these conditions, oral administration of medication cannot be achieved easily because highly acidic gastric fluid in the stomach contain enzymes that can break down the active drug before it reaches the target site. But Dr Sunil Bajpai and Ms Seema Dubey from the Polymer Research Laboratory at Government Model Science College in Jabalpur, India, produced a polymer gel into which a drug may be simply loaded.
The hydrogel system has been designed so that when swallowed by the patient, it passes through the stomach retaining the majority of the drug by protecting it from the stomach acids. 56 % of the drug is released where it is needed - further down the gastrointestinal tract in the colon. It is deposited when the gel swells in response to the colon’s (high) alkaline pH.
“The terpolymeric hydrogel system studied by our team provides an alternative to the parenteral medication of insulin. It is now necessary to carry out in vivo studies of this hydrogel system so that it could be further modified to produce oral delivery pills,” says Bajpai.