Progressive changes within the brain occur earlier in multiple sclerosis than previously supposed, according to a study presented October 4, 2004, at the 129th annual meeting of the American Neurological Association. Using sophisticated variations on magnetic resonance imaging (MRI) techniques, researchers described changes that appear in the first years of the disease, while disability is still minimal.
"The study showed that subtle abnormalities in the brain were steadily increasing during the first five years of multiple sclerosis, possibly reflecting changes to nerve fibers and their surrounding myelin sheathes," said Dr. Gerard Davies of the Institute of Neurology in London, lead author of the report.
Davies and colleagues also report preliminary evidence that the abnormalities may even pre-date the appearance of symptoms of the disorder.
Multiple sclerosis is an enigmatic disease of the nervous system and results in the loss of myelin, a substance that normally insulates nerve fibers and speeds electrical conduction through the fibers. Patches of inflammation (known as ‘plaques’) occur throughout the brain and spinal cord resulting in the loss of myelin and sometimes the nerve fibers themselves.
Depending on which nerve fibers are hindered, patients can experience problems ranging from weakness and clumsiness to numbness, visual disturbances, and even emotional and intellectual alterations. In patients such as the ones Davies and colleagues studied, MS manifests itself in cycles of relapse and remission and patients may show little sign of the disease between attacks.
The plaques are visible on standard MRI and are best seen within the ‘white matter’ areas of the brain and spinal cord, so called because they contain mostly nerve fibers, wrapped in light-colored mylein. This contrasts with the the ‘gray matter’, where the nerve cell bodies reside. Standard MRI can detect the white matter plaques but cannot pick up subtle changes that may be occurring between the plaques or in the gray matter.
As scientists have refined imaging techniques, they have begun to look at these previously unstudied areas and two important questions have emerged: How early does MRI-detectable damage occur, and, does the damage progress steadily during the first years after symptoms appear.