Carefully controlling the amount of food and drink that formerly sedentary, overweight people ingest during and after short-term exercise has a significant impact on insulin action.
The same study showed a measurable affect on the subjects’ cardiovascular disease (CVD) risk factors, according to researchers in the Exercise Science Department at the University of Massachusetts, Amherst.
After only six days of enough treadmill exercise to burn 500 kilocalories (k/cal) each day, the eight subjects in the negative energy balance (NEG) group, who received no energy replacement, showed a significant (p=0.037) 40% increase in insulin action (measured by glucose rate of disappearance/steady state insulin). However insulin action was unchanged in the zero energy balance group (ZERO), who were required to finish a sports drink during exercise and additional food afterward to “replace” the 500 k/cal.
The same subjects showed positive trends in both traditional and novel CVD risk factors, though not at a significant level. On the other hand, the subjects in the ZERO group showed either virtually no change or bad changes in CVD risk factors.
Both studies were performed on the same groups by Steven E. Black (a doctoral student) and Elizabeth Mitchell (an undergraduate honors student), both working in the laboratory of Barry Braun in the Department of Exercise Science, University of Massachusetts, Amherst. Black will present, “Improved insulin action following short-term exercise training: effects of exercise or energy balance?” while Mitchell will present “The effects of short-term exercise, in negative or zero energy balance, on CVD risk factors.”
One aspect of the research was to establish the role of energy balance in mediating improved insulin action after the short-term training. Insulin action was measured before the six days of exercise started and then again on the seventh day, after the fixed energy balance was over, by infusing glucose and very small quantities of a glucose stable isotope.
According to Black, “short-term exercise training in negative energy balance significantly reduced insulin resistance,” however, replacing energy lost while exercising “resulted in no change in insulin action.”
Black said the findings “suggest that subtle changes in energy balance that precede measurable fat loss play a key role in mediating the beneficial effects of exercise on whole-body insulin action.” Braun added: “The new finding is that the beneficial effect of exercise (in the short-term) appears to be mediated by a subtle mismatch between energy intake and expenditure. So, the ‘exercise’ effect can be opposed by adding back the energy expended during exercise. The implication is that the ‘exercise’ signal may be synonymous with an ‘energy deficit’ signal.”
The broad, important implications in the field of diabetes, Braun noted, is “both in the use of exercise to prevent or delay the transition from insulin resistance (prediabetes) to overt type-2 diabetes, and in the optimal use of exercise to manage blood sugar in people who already have diabetes.”