The location of body fat on older women can indicate the likelihood of heart disease, according to a new study published in The Journal of Clinical Endocrinology & Metabolism.
Researchers have identified a single factor that identifies women with metabolic syndrome (also called syndrome X), a cluster of disorders of your body's metabolism — including high blood pressure, high insulin levels, excess body weight and abnormal cholesterol levels — that make you more likely to develop diabetes, heart disease or stroke, according to Barbara Nicklas, Ph.D., principal investigator in the study.
"Everyone who is obese does not seem to be at the same risk for cardio-vascular disease. We were interested in why some obese people are at a higher disease risk than others," said Dr. Nicklas, associate professor in the section on gerontology and geriatric medicine in the department of internal medicine and the Center for Human Genomics at Wake Forest University School of Medicine in Winston-Salem, N.C. "In our study we used metabolic syndrome, a collection of five indicators, as a marker to differentiate women who were at a higher risk for subsequent cardiovascular disease."
In this study, Dr. Nicklas and her colleagues examined 58 obese, postmenopausal women, one-half of whom had metabolic syndrome, to determine whether four factors: aerobic fitness, body composition, body fat distribution and inflammation, differed between women with and without metabolic syndrome.
"We found that where the body fat is stored was the main determinant of who had metabolic syndrome," Dr. Nicklas said. "We were not just looking at whether the fat was carried on the hips or in the abdomen. We determined whether abdominal fat was stored between the skin and the abdominal muscle wall, what we call subcutaneous fat, or stored as visceral fat, which is beneath the muscles and wrapped around the internal organs. There have been a number of studies that indicate that visceral fat is worse because it surrounds vital organs and may lead to more fat metabolism by the liver."